Nolan J P
Yale J Biol Med. 1979 Jan-Feb;52(1):127-33.
The liver serves as the key organ for the removal and detoxification of bacterial endotoxins that are continously absorbed in small amounts from the gastrointestinal tract. This paper postulates that liver injury impairs this detoxification process leading to further liver damage and systemic effects as well. Evidence is reviewed to support the contention that endotoxin may be a major common pathway for liver injury by a variety of agents, and methods of reducing endotoxicity of gut origin are proposed. Finally, a new solid phase radioimmunometric assay for E. coli 026 is described and its usefulness as a gut marker suggested.
肝脏是清除和解毒细菌内毒素的关键器官，这些内毒素不断地从胃肠道少量吸收。本文推测肝脏损伤会损害这种解毒过程，进而导致进一步的肝脏损伤以及全身效应。文中回顾了相关证据以支持内毒素可能是多种因素导致肝损伤的主要共同途径这一论点，并提出了降低肠道源性内毒素毒性的方法。最后，描述了一种针对大肠杆菌026的新型固相放射免疫测定法，并指出其作为肠道标志物的用途。
