Wu Zhe, Yang Xuesong, Ruan Zhishen, Li Lianlian, Wu Jianlin, Wang Bin
The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Vascular Surgery, The First Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Nutr. 2023 Sep 18;10:1217465. doi: 10.3389/fnut.2023.1217465. eCollection 2023.
Calcium and magnesium are essential minerals that have significant roles in nerve function and regulation. There may be a correlation between dietary calcium and magnesium intake and peripheral neuropathy. However, this relationship remains unclear and requires further study.
Data from 7,726 participants in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004 were analyzed in this study. The relationship between total dietary calcium and magnesium intake, as well as each quantile, and peripheral neuropathy was analyzed using a multifactor logistic regression model. To illustrate the dose-response relationship between calcium and magnesium intake and peripheral neuropathy, we utilized a restricted cubic spline (RCS) plot.
Our analysis found a positive correlation between dietary intake of calcium and magnesium and peripheral neuropathy (calcium: OR 1.000, 95% CI 1.000-1.000; magnesium: OR 1.001, 95% CI 1.00-1.002). Participants in the first and third quantiles of dietary calcium intake had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.333, 95% CI 1.034-1.719, OR 1.497, 95% CI 1.155-1.941). Those in the first and third quantiles of dietary magnesium intake also had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.275, 95% CI 1.064-1.528, OR 1.525, 95% CI 1.231-1.890). The restricted cubic spline analysis revealed a U-shaped nonlinear relationship between dietary intake of calcium and magnesium and peripheral neuropathy.
The study found a U-shaped non-linear relationship between dietary calcium and magnesium intake levels and peripheral neuropathy, indicating that both excessive and insufficient intake of calcium and magnesium can increase the incidence of peripheral neuropathy.
钙和镁是必需矿物质，在神经功能和调节中发挥重要作用。膳食钙和镁摄入量与周围神经病变之间可能存在关联。然而，这种关系仍不明确，需要进一步研究。
本研究分析了1999年至2004年美国国家健康与营养检查调查（NHANES）中7726名参与者的数据。使用多因素逻辑回归模型分析膳食总钙和镁摄入量以及各分位数与周围神经病变之间的关系。为了阐明钙和镁摄入量与周围神经病变之间的剂量反应关系，我们使用了受限立方样条（RCS）图。
我们的分析发现膳食钙和镁摄入量与周围神经病变之间存在正相关（钙：比值比1.000，95%置信区间1.000 - 1.000；镁：比值比1.001，95%置信区间1.00 - 1.002）。膳食钙摄入量处于第一和第三分位数的参与者周围神经病变发病率显著高于处于第二分位数的参与者（比值比1.333，95%置信区间1.034 - 1.719，比值比1.497，95%置信区间1.155 - 1.941）。膳食镁摄入量处于第一和第三分位数的参与者周围神经病变发病率也显著高于处于第二分位数的参与者（比值比1.275，95%置信区间1.064 - 1.528，比值比1.525，95%置信区间1.231 - 1.890）。受限立方样条分析显示膳食钙和镁摄入量与周围神经病变之间呈U形非线性关系。
该研究发现膳食钙和镁摄入量水平与周围神经病变之间呈U形非线性关系，表明钙和镁摄入过多或过少均可增加周围神经病变的发病率。
