Dosimetry and Medical Radiation Physics Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Med Phys. 2023 Nov;50(11):7214-7221. doi: 10.1002/mp.16776. Epub 2023 Oct 4.
Independent dosimetry audits are an important intervention in radiotherapy for quality assurance. Electron beams, used for superficial radiotherapy treatments, must also be tested in dosimetry audits as part of a good quality assurance program to help prevent clinical errors.
To establish a new service for IAEA/WHO postal dosimetry audits in electron beams using RPL dosimeters.
A novel postal audit methodology employing a PMMA holder system for RPLDs was developed. The associated correction factors including holder dependence, energy dependence, dose response non-linearity, and fading were obtained and tested in a multi-center (n = 12) pilot study. A measurement uncertainty budget was estimated and employed in analyzing the irradiated dosimeters.
Holder and energy correction factors ranged from 1.004 to 1.010 and 1.019 to 1.059 respectively across the energy range. The non-linearity and fading correction models used for photon beams were tested in electron beams and did not significantly increase measurement uncertainty. The mean dose ratio ± SD of the multi-center study was 1.001 ± 0.011. The overall uncertainty budget was estimated as ± 1.42% (k = 1).
A methodology for IAEA/WHO postal dosimetry audits in electron beams was developed and validated in a multi-center study and is now made available to radiotherapy centers as a routine service.
独立剂量学审核是放射治疗质量保证的重要干预措施。电子束用于浅层放射治疗,也必须在剂量学审核中进行测试,作为良好质量保证计划的一部分,以帮助预防临床错误。
建立一种使用 RPL 剂量计对 IAEA/WHO 电子束邮寄剂量学审核的新服务。
开发了一种新颖的邮寄审核方法,该方法采用 PMMA 支架系统用于 RPLD。获得了相关的校正因子,包括支架依赖性、能量依赖性、剂量响应非线性和衰减,并在多中心(n=12)试点研究中进行了测试。估计了测量不确定度预算,并在分析辐照剂量计中使用。
支架和能量校正因子在整个能量范围内分别为 1.004 至 1.010 和 1.019 至 1.059。用于光子束的非线性和衰减校正模型在电子束中进行了测试,但并未显著增加测量不确定度。多中心研究的平均剂量比±SD 为 1.001±0.011。总体不确定度预算估计为±1.42%(k=1)。
已经开发并验证了一种用于 IAEA/WHO 电子束邮寄剂量学审核的方法,并在多中心研究中进行了验证,现在作为常规服务提供给放射治疗中心。