National Institute of Occupational Health, Oslo, Norway
Finnish Institute of Occupational Health, Työterveyslaitos, Finland.
BMJ Open. 2023 Oct 4;13(10):e075107. doi: 10.1136/bmjopen-2023-075107.
The objective of this study is to determine the effects of night work, Arctic seasonal factors and cold working environments on human functions relevant to safety. The study aims to quantify the contribution of (1) several consecutive night shifts, (2) seasonal variation on sleepiness, alertness and circadian rhythm and (3) whether a computational model of sleep, circadian rhythms and cognitive performance can accurately predict the observed sleepiness and alertness.
In an observational crossover study of outdoor and indoor workers (n=120) on a three-shift schedule from an industrial plant in Norway (70 °N), measurements will be conducted during the summer and winter. Sleep duration and quality will be measured daily by smartphone questionnaire, aided by actigraphy and heart rate measurements. Sleepiness and alertness will be assessed at regular intervals by the Karolinska Sleepiness Scale and the psychomotor vigilance test, respectively. Saliva samples will assess melatonin levels, and a blood sample will measure circadian time. Thermal exposures and responses will be measured by sensors and by thermography.
All participants will give written informed consent to participate in the study, which will be conducted in accordance with the Declaration of Helsinki. The Norwegian Regional Committee for Medical Research Ethics South-East D waivered the need for ethics approval (reference 495816). Dissemination plans include academic and lay publications, and partnerships with national and regional policymakers.
本研究旨在确定夜班、北极季节性因素和寒冷工作环境对与安全相关的人体功能的影响。本研究旨在量化以下因素的贡献:(1)连续几个夜班;(2)季节性对睡眠、警觉性和昼夜节律的影响;(3)是否可以通过睡眠、昼夜节律和认知表现的计算模型准确预测观察到的困倦和警觉性。
在挪威(70°N)一家工业工厂三班倒的户外和室内工人(n=120)的观察性交叉研究中,将在夏季和冬季进行测量。通过智能手机问卷、活动记录仪和心率测量来辅助,每日测量睡眠持续时间和质量。通过 Karolinska 睡眠量表和精神运动警觉性测试,定期评估困倦和警觉性。唾液样本将评估褪黑素水平,血液样本将测量昼夜节律时间。通过传感器和热成像测量热暴露和反应。
所有参与者都将书面同意参与研究,该研究将符合《赫尔辛基宣言》进行。挪威南部医学研究伦理委员会豁免了伦理批准的需要(参考号 495816)。传播计划包括学术和通俗出版物,以及与国家和地区政策制定者的合作。