Tan Xuejun, Xu Yukun, Zhou Sirui, Pan Mingyue, Cao Yue, Cai Xiuping, Zhao Qing, Zhao Kewei
The Third Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
J Inflamm Res. 2023 Sep 29;16:4363-4372. doi: 10.2147/JIR.S421124. eCollection 2023.
All humans are universally affected by inflammatory diseases, and there is an urgent need to identify new anti-inflammatory drugs with good therapeutic benefits and minimal side effects to the organism. Recently, it has been found that plant-derived vesicle-like nanoparticles (PDVLNs) have good biocompatibility, with their active ingredients exhibiting good therapeutic effects on inflammation. They can also be used as drug carriers for targeted delivery of anti-inflammatory drugs. Therefore, PDVLNs represent a popular research area for novel anti-inflammatory drugs. This paper details the origin, biological functions, isolation and purification, and identification of PDVLNs, as well as the therapeutic effects of their intrinsic bioactive components on inflammatory diseases. It also introduces their targets as drug carriers to facilitate the development and application of PDVLNs anti-inflammatory drugs.
所有人都会普遍受到炎症性疾病的影响，因此迫切需要研发出具有良好治疗效果且对机体副作用最小的新型抗炎药物。最近，人们发现植物源囊泡样纳米颗粒（PDVLNs）具有良好的生物相容性，其活性成分对炎症具有良好的治疗效果。它们还可以用作抗炎药物靶向递送的药物载体。因此，PDVLNs是新型抗炎药物的一个热门研究领域。本文详细介绍了PDVLNs的起源、生物学功能、分离纯化和鉴定，以及其内在生物活性成分对炎症性疾病的治疗作用。此外，还介绍了它们作为药物载体的靶点，以促进PDVLNs抗炎药物的开发和应用。
