Department of Nephrology, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, 310000, People's Republic of China.
Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Int J Nanomedicine. 2023 Oct 6;18:5671-5683. doi: 10.2147/IJN.S428647. eCollection 2023.
The utilization of plant-derived vesicle-like nanoparticles (PDVLNs) has shown effectiveness in the prevention/treatment of inflammatory-mediated diseases, malignancies, and immune-related diseases, such as acute liver injury, allergic asthma, gastric cancer and so on. This highlights the promising potential of PDVLNs as biotherapeutics. Furthermore, it should be noted that PDVLNs possess the ability to function as both natural and engineered drug carriers, making them an appealing option. This review aims to present the appropriate extraction methods of PDVLNs, summarize the applications of PDVLNs in different diseases, and provide an outlook on the prospects of PDVLNs. At the same time, the authors also express their discussion on the current limitations of PDVLNs.
植物来源的囊泡样纳米颗粒（PDVLNs）在预防/治疗炎症介导的疾病、恶性肿瘤和免疫相关疾病方面显示出了有效性，如急性肝损伤、过敏性哮喘、胃癌等。这突出了 PDVLNs 作为生物治疗药物的巨大潜力。此外，值得注意的是，PDVLNs 具有作为天然和工程药物载体的双重功能，这使其成为一种有吸引力的选择。本综述旨在介绍 PDVLNs 的适当提取方法，总结 PDVLNs 在不同疾病中的应用，并对 PDVLNs 的前景进行展望。同时，作者还对 PDVLNs 的当前局限性进行了讨论。
