Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, China.
Department of Gynaecology, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Nutr J. 2023 Oct 6;22(1):48. doi: 10.1186/s12937-023-00873-6.
The relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease and mortality in dyslipidemic patients is unclear. Men with dyslipidemia have a higher risk of cardiovascular disease than women, and PUFA supplementation may be more beneficial in men.
The purpose of this study was to assess the relationship between different types of marine polyunsaturated fatty acids intakes and cardiovascular disease, all-cause mortality, and cardiovascular mortality in adult U.S. males with dyslipidemia.
The study ultimately included 11,848 adult men with dyslipidemia who were screened from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2016. This was linked to the 2019 National Death Index (NDI) records to establish a prospective cohort. In the study, a logistic regression model was established to assess the relationship between PUFA intake and prevalent CVD, and a Cox proportional hazards regression model was established to assess the relationship between PUFA intake and death.
In the fully adjusted models, compared with participants in the lowest tertile, participants with the highest DPA intake were associated with a lower risk of CVD (CVD: OR = 0.71, 95%CI: 0.55, 0.91; angina: OR = 0.54, 95%CI: 0.38, 0.79; stroke: OR = 0.62, 95%CI: 0.43, 0.89), but not with three subtypes of congestive heart failure, coronary heart disease, and myocardial infarction. And the highest tertile level of DPA intake can reduce all-cause mortality (HR = 0.77, 95%CI: 0.64, 0.91) and CVD mortality (HR = 0.68, 95%CI: 0.52, 0.90).
Cardiovascular disease risk, all-cause mortality, and CVD mortality were inversely associated with dietary DPA intake but not EPA and DHA intakes in U.S. male participants with dyslipidemia.
海洋多不饱和脂肪酸（PUFA）的摄入量与血脂异常患者的心血管疾病和死亡率之间的关系尚不清楚。血脂异常男性患心血管疾病的风险高于女性，而 PUFA 补充剂可能对男性更有益。
本研究旨在评估不同类型的海洋多不饱和脂肪酸摄入量与美国血脂异常成年男性心血管疾病、全因死亡率和心血管死亡率之间的关系。
本研究最终纳入了 2001 年至 2016 年期间从国家健康和营养检查调查（NHANES）中筛选出的 11848 名血脂异常成年男性。这些数据与 2019 年国家死亡指数（NDI）记录相关联，建立了一个前瞻性队列。在研究中，建立了逻辑回归模型来评估 PUFA 摄入量与常见心血管疾病的关系，建立了 Cox 比例风险回归模型来评估 PUFA 摄入量与死亡的关系。
在完全调整模型中，与最低三分位组相比，最高 DPA 摄入量组的心血管疾病风险较低（心血管疾病：OR=0.71，95%CI：0.55，0.91；心绞痛：OR=0.54，95%CI：0.38，0.79；中风：OR=0.62，95%CI：0.43，0.89），但与充血性心力衰竭、冠心病和心肌梗死的三个亚型无关。最高 DPA 摄入量三分位组可以降低全因死亡率（HR=0.77，95%CI：0.64，0.91）和心血管疾病死亡率（HR=0.68，95%CI：0.52，0.90）。
在血脂异常的美国男性参与者中，膳食 DPA 摄入与心血管疾病风险、全因死亡率和心血管死亡率呈负相关，而 EPA 和 DHA 摄入与这些结局无关。
