Tan Hong-Hu, Xia Meng, Su Ping, Huang Lu-Qi
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2023 Sep;48(17):4620-4633. doi: 10.19540/j.cnki.cjcmm.20230427.201.
Tigliane type macrocyclic diterpenoids with special structures and diverse bioactivities are mainly extracted from plants of Euphorbiaceae and Thymelaeaceae. According to the different functional groups, they can be classified into types of phorbol esters, C-4 deoxyphorbol esters, C-12 deoxyphorbol esters, C-16 or C-17 substituted phorbol esters and others. Most of them present promising antiviral activities and cytotoxic activities and are expected to be developed as candidates for anti-AIDS, anti-tuberculosis, and anti-tumor clinical trials, demonstrating great potential for the application in healthcare. This paper reviews 115 novel tigliane-type diterpenoids discovered since 2013 and summarize their chemical structures and bioactivities, aiming to lay a foundation for further development and utilization of these compounds and provide new ideas for the development of clinical drugs.
具有特殊结构和多样生物活性的大戟烷型大环二萜类化合物主要从大戟科和瑞香科植物中提取。根据官能团的不同，它们可分为佛波酯类、C-4脱氧佛波酯类、C-12脱氧佛波酯类、C-16或C-17取代佛波酯类等。它们中的大多数具有良好的抗病毒活性和细胞毒性活性，有望被开发为抗艾滋病、抗结核病和抗肿瘤临床试验的候选药物，在医疗保健应用中显示出巨大潜力。本文综述了2013年以来发现的115种新型大戟烷型二萜类化合物，总结了它们的化学结构和生物活性，旨在为这些化合物的进一步开发利用奠定基础，并为临床药物的开发提供新思路。
