Department of Spinal Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Curr Med Chem. 2024;31(18):2629-2648. doi: 10.2174/0109298673258420230919103405.
Ferroptosis is a newly discovered non-apoptotic cell death whose key is lipid peroxidation. It has been reported that ferroptosis is involved in the occurrence and development of tumors and nervous system and musculoskeletal diseases. Cellular ferroptosis contributes to the imbalance of bone homeostasis and is involved in the development of osteoporosis; however, the detailed mechanism of which is still unclear though it may provide a new direction for anti-osteoporosis. The current drugs used in the treatment of osteoporosis, such as bisphosphonates and teriparatide, have many side effects, increasing people's search for natural compounds to treat osteoporosis. This review paper briefly summarizes the current research regarding the mechanisms of ferroptosis and natural anti-osteoporosis compounds targeting its pathway.
铁死亡是一种新发现的非细胞凋亡性细胞死亡方式，其关键在于脂质过氧化。有报道称，铁死亡参与了肿瘤和神经系统及肌肉骨骼疾病的发生和发展。细胞铁死亡导致骨稳态失衡，并参与骨质疏松症的发生；然而，其详细机制尚不清楚，尽管它可能为抗骨质疏松症提供新的方向。目前用于治疗骨质疏松症的药物，如双磷酸盐类和特立帕肽类，有许多副作用，这增加了人们对天然化合物治疗骨质疏松症的探索。本文简要总结了铁死亡的机制以及针对其通路的天然抗骨质疏松化合物的研究现状。
