Xi Yujie, Gao Ling, Li Shaming, Sun Kai, Chen Peishen, Cai Zhen, Ren Wenhao, Zhi Keqian
Department of Oral and Maxillofacial Reconstruction, The Affiliated Hospital of Qingdao University, Qingdao, China.
Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Front Pharmacol. 2023 Sep 25;14:1228985. doi: 10.3389/fphar.2023.1228985. eCollection 2023.
Head and neck squamous cell carcinoma (HNSCC) is a common oral cancer with poor prognosis and for which no targeted therapeutic strategies are currently available. Accumulating evidence has demonstrated that programmed cell death (PCD) is essential in the development of HNSCC as a second messenger. PCD can be categorized into numerous different subroutines: in addition to the two well-known types of apoptosis and autophagy, novel forms of programmed cell death (e.g., necroptosis, pyroptosis, ferroptosis, and NETosis) also serve as key alternatives in tumorigenesis. Cancer cells are not able to avoid all types of cell death simultaneously, since different cell death subroutines follow different regulatory pathways. Herein, we summarize the roles of novel programmed cell death in tumorigenesis and present our interpretations of the molecular mechanisms with a view to the development of further potential therapies.
头颈部鳞状细胞癌（HNSCC）是一种常见的口腔癌，预后较差，目前尚无靶向治疗策略。越来越多的证据表明，程序性细胞死亡（PCD）作为第二信使在HNSCC的发展中至关重要。PCD可分为许多不同的子程序：除了两种众所周知的凋亡和自噬类型外，新型程序性细胞死亡形式（如坏死性凋亡、炎性小体介导的细胞焦亡、铁死亡和中性粒细胞胞外陷阱形成）在肿瘤发生中也起着关键作用。癌细胞无法同时避免所有类型的细胞死亡，因为不同的细胞死亡子程序遵循不同的调控途径。在此，我们总结了新型程序性细胞死亡在肿瘤发生中的作用，并对分子机制进行了解读，以期开发出更多潜在的治疗方法。
