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中性粒细胞明胶酶相关脂质运载蛋白血清水平：子宫内膜异位症的一种潜在非侵入性生物标志物？

Neutrophil gelatinase-associated lipocalin serum level: A potential noninvasive biomarker of endometriosis?

机构信息

Department of Reproductive Endocrinology and Infertility, Balikesir University Medical Faculty, Balikesir, Turkey.

Unit of Gynecologic Oncology, ARNAS "Civico-Di Cristina-Benfratelli," Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.

出版信息

Medicine (Baltimore). 2023 Oct 13;102(41):e35539. doi: 10.1097/MD.0000000000035539.

DOI:10.1097/MD.0000000000035539
PMID:37832065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10578740/
Abstract

Neutrophil gelatinase-associated lipocalin (NGAL, also known as lipocalin-2) is an acute-phase protein expressed in many tissues and plays a role in cell proliferation, regulation, and epithelial-mesenchymal transformation. Therefore, this study aimed to investigate serum NGAL levels and endometrioma tissue expression in women with endometriosis. This cross-sectional study was conducted at a university hospital. The endometrioma group included 36 women who underwent ovarian cystectomy for endometrioma, which was compared with a control group (n = 36) of women who underwent ovarian cystectomy due to benign persistent cysts (follicle cyst, theca lutein cyst, and serous cystadenoma). NGAL levels were analyzed using both serum enzyme-linked immunosorbent assay analysis and immunohistochemical tissue staining. Serum C-reactive protein and CA-125 levels were also evaluated. NGAL serum levels were significantly higher in the endometrioma group than in the control group (P < .05). C-reactive protein and CA-125 levels were also significantly higher in the endometrioma group (P < .05) and were correlated with NGAL levels. Immunohistochemical staining for NGAL was also higher in the endometrioma group (P < .001). NGAL may be considered a potential noninvasive biomarker of endometriosis.

摘要

中性粒细胞明胶酶相关脂质运载蛋白（NGAL，也称为脂质运载蛋白-2）是一种急性期蛋白，在许多组织中表达，在细胞增殖、调节和上皮-间充质转化中发挥作用。因此，本研究旨在探讨子宫内膜异位症患者血清 NGAL 水平和子宫内膜异位症组织表达。这项横断面研究在一所大学医院进行。内异症组包括 36 例行卵巢囊肿切除术的子宫内膜异位症患者，与因良性持续囊肿（卵泡囊肿、黄体囊肿和浆液性囊腺瘤）而行卵巢囊肿切除术的对照组（n=36）进行比较。使用血清酶联免疫吸附试验分析和免疫组织化学组织染色分析 NGAL 水平。还评估了血清 C 反应蛋白和 CA-125 水平。内异症组的血清 NGAL 水平明显高于对照组（P<.05）。内异症组的 C 反应蛋白和 CA-125 水平也明显升高（P<.05），且与 NGAL 水平相关。NGAL 的免疫组织化学染色在子宫内膜异位症组也更高（P<.001）。NGAL 可能被认为是子宫内膜异位症的一种潜在的非侵入性生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/a2714dec4699/medi-102-e35539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/80eb956b1979/medi-102-e35539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/b263ef5c13ab/medi-102-e35539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/a2714dec4699/medi-102-e35539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/80eb956b1979/medi-102-e35539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/b263ef5c13ab/medi-102-e35539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aac/10578740/a2714dec4699/medi-102-e35539-g003.jpg

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Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement.子宫内膜异位症：病理生理学、（表观）遗传学及环境因素影响的最新进展
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