Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, the Netherlands; Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences, University of Amsterdam, 1090 GE Amsterdam, the Netherlands.
Cell Rep. 2023 Oct 31;42(10):113249. doi: 10.1016/j.celrep.2023.113249. Epub 2023 Oct 12.
Cognitive functioning requires coordination between brain areas. Between visual areas, feedforward gamma synchronization improves behavioral performance. Here, we investigate whether similar principles hold across brain regions and frequency bands, using simultaneous electrocorticographic recordings from 15 areas of two macaque monkeys during performance of a selective attention task. Short behavioral reaction times (RTs), suggesting efficient interareal communication, occurred when occipital areas V1, V2, V4, and DP showed gamma synchronization, and fronto-central areas S1, 5, F1, F2, and F4 showed beta synchronization. For both area clusters and corresponding frequency bands, deviations from the typically observed phase relations increased RTs. Across clusters and frequency bands, good phase relations occurred in a correlated manner specifically when they processed the behaviorally relevant stimulus. Furthermore, the fronto-central cluster exerted a beta-band influence onto the occipital cluster whose strength predicted short RTs. These results suggest that local gamma and beta synchronization and their inter-regional coordination jointly improve behavioral performance.
认知功能需要大脑区域之间的协调。在视觉区域之间，前馈伽马同步可以提高行为表现。在这里，我们使用两只猕猴的 15 个脑区的同时皮层电图记录，在执行选择性注意任务期间，研究了这些原则是否在不同的脑区和频带中都适用。当枕叶区域 V1、V2、V4 和 DP 显示伽马同步，并且额-中央区域 S1、5、F1、F2 和 F4 显示β同步时，出现较短的行为反应时间 (RT)，这表明区域间的通信效率较高。对于这两个区域集群和相应的频带，偏离通常观察到的相位关系会增加 RT。在集群和频带之间，当它们处理与行为相关的刺激时，良好的相位关系以相关的方式出现。此外，额-中央集群对枕叶集群施加β频带影响，其强度可以预测短的 RT。这些结果表明，局部伽马和β同步及其区域间的协调共同提高了行为表现。
