Hewlett T P, McMartin K E, Lauro A J, Ragan F A
J Toxicol Clin Toxicol. 1986;24(5):389-402. doi: 10.3109/15563658608992602.
Glycolic acid is the ethylene glycol (EG) metabolite that accumulates in the highest concentrations in the blood and may be the major contributing factor to the acute toxicity of EG. Serum and urine levels of glycolic acid have been found to correlate directly with clinical symptoms and mortality in poisoning cases, making it a valuable diagnostic tool. A high pressure liquid chromatographic (HPLC) method for quantitation of glycolic acid in serum was used in several cases of EG ingestion presented to the Louisiana Regional Poison Control Center. The data collected in this study support the value of glycolic acid determination for diagnosis and evaluation of patients poisoned by EG.
乙醇酸是乙二醇（EG）的代谢产物，在血液中以最高浓度蓄积，可能是乙二醇急性毒性的主要促成因素。已发现乙醇酸的血清和尿液水平与中毒病例的临床症状和死亡率直接相关，使其成为一种有价值的诊断工具。路易斯安那州区域中毒控制中心收治的几例乙二醇摄入病例采用了一种高压液相色谱（HPLC）法来定量血清中的乙醇酸。本研究收集的数据支持测定乙醇酸对诊断和评估乙二醇中毒患者的价值。
