Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Hum Brain Mapp. 2023 Dec 1;44(17):6139-6148. doi: 10.1002/hbm.26502. Epub 2023 Oct 16.
Brain age prediction algorithms using structural magnetic resonance imaging (MRI) aim to assess the biological age of the human brain. The difference between a person's chronological age and the estimated brain age is thought to reflect deviations from a normal aging trajectory, indicating a slower or accelerated biological aging process. Several pre-trained software packages for predicting brain age are publicly available. In this study, we perform a comparison of such packages with respect to (1) predictive accuracy, (2) test-retest reliability, and (3) the ability to track age progression over time. We evaluated the six brain age prediction packages: brainageR, DeepBrainNet, brainage, ENIGMA, pyment, and mccqrnn. The accuracy and test-retest reliability were assessed on MRI data from 372 healthy people aged between 18.4 and 86.2 years (mean 38.7 ± 17.5 years). All packages showed significant correlations between predicted brain age and chronological age (r = 0.66-0.97, p < 0.001), with pyment displaying the strongest correlation. The mean absolute error was between 3.56 (pyment) and 9.54 years (ENIGMA). brainageR, pyment, and mccqrnn were superior in terms of reliability (ICC values between 0.94-0.98), as well as predicting age progression over a longer time span. Of the six packages, pyment and brainageR consistently showed the highest accuracy and test-retest reliability.
利用结构磁共振成像(MRI)预测大脑年龄的算法旨在评估人类大脑的生物年龄。一个人与实际年龄的差异被认为反映了与正常衰老轨迹的偏差,表明生物衰老过程较慢或加速。有几个用于预测大脑年龄的预训练软件包可供公开使用。在这项研究中,我们对这些软件包进行了比较,比较了(1)预测准确性,(2)测试-重测可靠性,以及(3)随时间跟踪年龄进展的能力。我们评估了六个大脑年龄预测软件包:brainageR、DeepBrainNet、brainage、ENIGMA、pyment 和 mccqrnn。在 372 名年龄在 18.4 至 86.2 岁(平均 38.7 ± 17.5 岁)的健康人中,对 MRI 数据进行了准确性和测试-重测可靠性评估。所有软件包均显示出预测大脑年龄与实际年龄之间存在显著相关性(r=0.66-0.97,p<0.001),pyment 相关性最强。平均绝对误差在 3.56(pyment)至 9.54 岁(ENIGMA)之间。brainageR、pyment 和 mccqrnn 在可靠性方面表现更好(ICC 值在 0.94-0.98 之间),并且能够预测更长时间跨度的年龄进展。在这六个软件包中,pyment 和 brainageR 始终表现出最高的准确性和测试-重测可靠性。