• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

药物再利用:创新、科学和潜力的交汇点。

Drug repurposing: a nexus of innovation, science, and potential.

机构信息

Institute of Chemical Sciences and Technologies "Giulio Natta" (SCITEC) - CNR, L.go F. Vito 1, 00168, Rome, Italy.

Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India.

出版信息

Sci Rep. 2023 Oct 19;13(1):17887. doi: 10.1038/s41598-023-44264-7.

DOI:10.1038/s41598-023-44264-7
PMID:37857641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10587351/
Abstract

The urgency of finding therapeutic solutions for emerging and existing health challenges has never been more pronounced. In the pursuit of this goal, the value of a strategy that makes use of existing resources is being recognized: drug repurposing or repositioning of compounds for new indications. Such approaches are employed against cancer, rheumatoid arthritis, multiple sclerosis, HIV/AIDS, and many other diseases. This Collection, aptly titled “Drug Repurposing”, includes research and perspectives from scientists at the forefront of this innovative field.

摘要

对于新发和现有健康挑战的治疗方法的需求从未如此迫切。在追求这一目标的过程中,人们越来越认识到利用现有资源的策略的价值:重新利用或重新定位化合物以用于新的适应症。这种方法被用于治疗癌症、类风湿性关节炎、多发性硬化症、艾滋病等许多疾病。本合集恰当地题为“药物再利用”,其中包含处于这一创新领域前沿的科学家们的研究和观点。

相似文献

1
Drug repurposing: a nexus of innovation, science, and potential.药物再利用:创新、科学和潜力的交汇点。
Sci Rep. 2023 Oct 19;13(1):17887. doi: 10.1038/s41598-023-44264-7.
2
Multi-Omics and Artificial Intelligence-Guided Drug Repositioning: Prospects, Challenges, and Lessons Learned from COVID-19.多组学和人工智能指导的药物重定位:从 COVID-19 中得到的前景、挑战和经验教训。
OMICS. 2022 Jul;26(7):361-371. doi: 10.1089/omi.2022.0068. Epub 2022 Jun 28.
3
Renovation as innovation: is repurposing the future of drug discovery research?翻新即创新:药物研发的未来在于重新利用现有药物吗?
Drug Discov Today. 2019 Jan;24(1):1-3. doi: 10.1016/j.drudis.2018.06.012. Epub 2018 Jun 21.
4
Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?药物重新利用真的是药物研发的未来吗?还是全新的创新才是真正的前进方向?
Expert Opin Drug Discov. 2021 Aug;16(8):829-831. doi: 10.1080/17460441.2021.1912733. Epub 2021 Apr 23.
5
In silico drug repositioning: what we need to know.计算机药物重定位:我们需要了解的内容。
Drug Discov Today. 2013 Feb;18(3-4):110-5. doi: 10.1016/j.drudis.2012.08.005. Epub 2012 Aug 28.
6
Revisiting Repurposing.重新审视重新利用
Assay Drug Dev Technol. 2016 Dec;14(10):554-556. doi: 10.1089/adt.2016.766.
7
Computational Drug Repurposing: Classification of the Research Opportunities and Challenges.计算药物再利用:研究机遇与挑战分类。
Curr Comput Aided Drug Des. 2020;16(4):354-364. doi: 10.2174/1573409915666190613113822.
8
Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing.新型抗生素开发方法与挑战简述:以药物再利用为重点
Front Cell Infect Microbiol. 2021 May 17;11:684515. doi: 10.3389/fcimb.2021.684515. eCollection 2021.
9
Advancing drug repurposing research: Trends, collaborative networks, innovation and knowledge leaders.推进药物再利用研究:趋势、合作网络、创新和知识领袖。
Drug Discov Today. 2022 Dec;27(12):103396. doi: 10.1016/j.drudis.2022.103396. Epub 2022 Oct 12.
10
[Data-driven drug discovery for drug repurposing].[用于药物重新利用的数据驱动药物发现]
Nihon Yakurigaku Zasshi. 2023;158(1):10-14. doi: 10.1254/fpj.22072.

引用本文的文献

1
Anti-EBV: Artificial intelligence driven predictive modeling for repurposing drugs as potential antivirals against Epstein-Barr virus.抗EBV:人工智能驱动的预测模型,用于将药物重新用作针对爱泼斯坦-巴尔病毒的潜在抗病毒药物。
Comput Struct Biotechnol J. 2025 May 1;27:1784-1799. doi: 10.1016/j.csbj.2025.04.042. eCollection 2025.
2
Approaches to repurposing reverse transcriptase antivirals in cancer.癌症中逆转录酶抗病毒药物的重新利用方法。
Br J Clin Pharmacol. 2025 Sep;91(9):2494-2506. doi: 10.1002/bcp.70113. Epub 2025 May 28.
3
Novel target identification towards drug repurposing based on biological activity profiles.基于生物活性谱的药物再利用新靶点识别
PLoS One. 2025 May 6;20(5):e0319865. doi: 10.1371/journal.pone.0319865. eCollection 2025.
4
Drug Repurposing and Nanotechnology for Topical Skin Cancer Treatment: Redirecting toward Targeted and Synergistic Antitumor Effects.用于局部皮肤癌治疗的药物再利用与纳米技术:转向靶向和协同抗肿瘤效应
ACS Pharmacol Transl Sci. 2025 Jan 23;8(2):308-338. doi: 10.1021/acsptsci.4c00679. eCollection 2025 Feb 14.
5
Antiviral Development for the Polio Endgame: Current Progress and Future Directions.脊髓灰质炎终结阶段的抗病毒药物研发:当前进展与未来方向
Pathogens. 2024 Nov 6;13(11):969. doi: 10.3390/pathogens13110969.
6
AI in Clinical Trials and Drug Development: Challenges and Potential Advancements.人工智能在临床试验和药物研发中的挑战与潜在进展
Curr Drug Discov Technol. 2024 Oct 28. doi: 10.2174/0115701638314252241016165345.
7
Metal chelation as an antibacterial strategy for and .金属螯合作为[具体对象1]和[具体对象2]的抗菌策略。 (原文中“for and.”表述不完整,推测可能是这种意思)
RSC Chem Biol. 2024 Sep 24;5(11):1083-96. doi: 10.1039/d4cb00175c.
8
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions.一种发现潜在结直肠癌化疗药物的高通量筛选方法:重新利用药物破坏14-3-3蛋白与BAD的相互作用。
bioRxiv. 2023 Dec 15:2023.12.14.571727. doi: 10.1101/2023.12.14.571727.

本文引用的文献

1
Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX.利用 DrugSolver CavitomiX 鉴定并验证夫西地酸和氟芬那酸抑制 SARS-CoV-2 复制的效果。
Sci Rep. 2023 Jul 21;13(1):11783. doi: 10.1038/s41598-023-39071-z.
2
An interaction-based drug discovery screen explains known SARS-CoV-2 inhibitors and predicts new compound scaffolds.基于相互作用的药物发现筛选解释了已知的 SARS-CoV-2 抑制剂,并预测了新的化合物支架。
Sci Rep. 2023 Jun 6;13(1):9204. doi: 10.1038/s41598-023-35671-x.
3
Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface.虚拟筛选和分子动力学模拟为针对 SARS-CoV-2 变体 Spike 蛋白/ACE2 界面的药物再利用提供了深入了解。
Sci Rep. 2023 Jan 27;13(1):1494. doi: 10.1038/s41598-023-28716-8.
4
Single-cell-led drug repurposing for Alzheimer's disease.基于单细胞的阿尔茨海默病药物再利用。
Sci Rep. 2023 Jan 5;13(1):222. doi: 10.1038/s41598-023-27420-x.
5
KUALA: a machine learning-driven framework for kinase inhibitors repositioning.KUALA:一种基于机器学习的激酶抑制剂再定位框架。
Sci Rep. 2022 Oct 25;12(1):17877. doi: 10.1038/s41598-022-22324-8.
6
Drug repurposing: progress, challenges and recommendations.药物重定位:进展、挑战和建议。
Nat Rev Drug Discov. 2019 Jan;18(1):41-58. doi: 10.1038/nrd.2018.168. Epub 2018 Oct 12.
7
Prediction of Chemical Toxicity for Drug Design Using Machine Learning Methods and Structural Alerts.使用机器学习方法和结构警示进行药物设计的化学毒性预测
Front Chem. 2018 Feb 20;6:30. doi: 10.3389/fchem.2018.00030. eCollection 2018.
8
Natural Products as Platforms To Overcome Antibiotic Resistance.作为克服抗生素耐药性平台的天然产物
Chem Rev. 2017 Oct 11;117(19):12415-12474. doi: 10.1021/acs.chemrev.7b00283. Epub 2017 Sep 27.
9
Pharos: Collating protein information to shed light on the druggable genome.法罗斯计划:整理蛋白质信息以揭示药物基因组。
Nucleic Acids Res. 2017 Jan 4;45(D1):D995-D1002. doi: 10.1093/nar/gkw1072. Epub 2016 Nov 29.