Kaloğlu Hatice Ayça, Örsel Sibel, Erzin Gamze
Department of Psychiatry, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Clin Psychopharmacol Neurosci. 2023 Nov 30;21(4):724-731. doi: 10.9758/cpn.22.1030. Epub 2023 Jun 29.
: Irisin is a myokine that is involved in neurogenesis, neuronal proliferation, and neuronal differentiation. Many research examine the relationship between irisin and schizophrenia. In this study, we aimed to evaluate the relationship between irisin levels and cognitive functions in individuals with schizophrenia.
: Ninety-six individuals who were diagnosed with schizophrenia were included. The Brief Psychiatric Rating Scale (BPRS) was used to assess disease severity. To evaluate the cognitive functions of the patients, the trail-making test was evaluated with the A and B forms and the verbal memory processes scale. After a 12-hour night fast, samples of fasting blood were obtained from the participants.
: There was no significant correlation between irisin, duration of disease, and BPRS total score. In the analysis performed, a positive correlation was found between the plasma irisin level and the error score of the trail-making test form B. Other than that, no correlation was found between irisin level and cognitive performance in schizophrenia patients. In addition, in subgroup analysis between genders, it was determined that the duration of the trail-making test B was longer in female schizophrenia patients.
: In this study, there was a positive correlation between the trail-making test B-form error scores and the irisin levels. This relationship between impaired executive functions and irisin levels may suggest that the irisin level is increased as compensation for the impairment in executive functions. More research is needed to understand the role of irisin in cognitive impairment and schizophrenia.
鸢尾素是一种参与神经发生、神经元增殖和神经元分化的肌动蛋白。许多研究探讨了鸢尾素与精神分裂症之间的关系。在本研究中，我们旨在评估精神分裂症患者鸢尾素水平与认知功能之间的关系。
纳入96例被诊断为精神分裂症的个体。使用简明精神病评定量表（BPRS）评估疾病严重程度。为评估患者的认知功能，采用A、B两种形式的连线测验和言语记忆过程量表进行评估。在禁食12小时后，采集参与者的空腹血样。
鸢尾素、病程和BPRS总分之间无显著相关性。在进行的分析中，发现血浆鸢尾素水平与连线测验B型错误得分呈正相关。除此之外，未发现鸢尾素水平与精神分裂症患者认知表现之间存在相关性。此外，在性别亚组分析中，确定女性精神分裂症患者的连线测验B型用时更长。
在本研究中，连线测验B型错误得分与鸢尾素水平呈正相关。执行功能受损与鸢尾素水平之间的这种关系可能表明，鸢尾素水平升高是对执行功能受损的一种代偿。需要更多研究来了解鸢尾素在认知障碍和精神分裂症中的作用。
