Xu Jin-Zhou, Xia Qi-Dong, Sun Jian-Xuan, Liu Chen-Qian, Lu Jun-Lin, Xu Meng-Yao, An Ye, Xun Yang, Liu Zheng, Hu Jia, Li Cong, Wang Shao-Gang
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sci Rep. 2023 Oct 20;13(1):17911. doi: 10.1038/s41598-023-44700-8.
Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors. Accordingly, we herein established an indicator to evaluate pyroptosis related gene transcription levels based on the expression level of genes involved in pyroptosis and tried to elaborated on the association between pyroptosis and tumors across diverse tumor types. We found that pyroptosis related gene transcription levels could predict the prognosis of patients, which could act as either a favorable or a dreadful factor in diverse cancers. According to signaling pathway analyses we observed that pyroptosis played a significant role in immune regulation and tumorigenesis and had strong links with other forms of cell death. We also performed analysis on the crosstalk between pyroptosis and immune status and further investigated the predictive potential of pyroptosis level for the efficacy of immunotherapy. Lastly, we manifested that pyroptosis status could serve as a biomarker to the efficacy of chemotherapy across various cancers. In summary, this study established a quantitative indicator to evaluate pyroptosis related gene transcription levels, systematically explored the role of pyroptosis in pan-cancer. These results could provide potential research directions targeting pyroptosis, and highlighted that pyroptosis may be used to develop a novel strategy for the treatment of cancer.
细胞焦亡是一种程序性细胞死亡，在不同癌症中发挥双重作用。评估细胞焦亡的激活水平以及评估细胞焦亡在各种肿瘤发生和发展中的参与情况尚不清楚。因此，我们在此基于参与细胞焦亡的基因表达水平建立了一个评估细胞焦亡相关基因转录水平的指标，并试图阐述细胞焦亡与不同肿瘤类型肿瘤之间的关联。我们发现细胞焦亡相关基因转录水平可以预测患者的预后，这在不同癌症中既可以是一个有利因素，也可以是一个可怕因素。根据信号通路分析，我们观察到细胞焦亡在免疫调节和肿瘤发生中起重要作用，并且与其他形式的细胞死亡有密切联系。我们还对细胞焦亡与免疫状态之间的相互作用进行了分析，并进一步研究了细胞焦亡水平对免疫治疗疗效的预测潜力。最后，我们表明细胞焦亡状态可以作为各种癌症化疗疗效的生物标志物。总之，本研究建立了一个评估细胞焦亡相关基因转录水平的定量指标，系统地探索了细胞焦亡在泛癌中的作用。这些结果可以为针对细胞焦亡的潜在研究方向提供依据，并强调细胞焦亡可用于开发一种新的癌症治疗策略。
