Han Seokgyu, Cruz Sebastián Herrera, Park Sungsu, Shin Su Ryon
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Korea.
Nano Converg. 2023 Oct 21;10(1):48. doi: 10.1186/s40580-023-00398-y.
Engineered three-dimensional (3D) tissue constructs have emerged as a promising solution for regenerating damaged muscle tissue resulting from traumatic or surgical events. 3D architecture and function of the muscle tissue constructs can be customized by selecting types of biomaterials and cells that can be engineered with desired shapes and sizes through various nano- and micro-fabrication techniques. Despite significant progress in this field, further research is needed to improve, in terms of biomaterials properties and fabrication techniques, the resemblance of function and complex architecture of engineered constructs to native muscle tissues, potentially enhancing muscle tissue regeneration and restoring muscle function. In this review, we discuss the latest trends in using nano-biomaterials and advanced nano-/micro-fabrication techniques for creating 3D muscle tissue constructs and their regeneration ability. Current challenges and potential solutions are highlighted, and we discuss the implications and opportunities of a future perspective in the field, including the possibility for creating personalized and biomanufacturable platforms.
工程化三维（3D）组织构建体已成为一种有前景的解决方案，用于修复因创伤或手术事件导致的受损肌肉组织。通过选择生物材料和细胞类型，肌肉组织构建体的3D结构和功能可以通过各种纳米和微制造技术定制成所需的形状和尺寸。尽管该领域取得了重大进展，但仍需要进一步研究，在生物材料特性和制造技术方面，提高工程构建体的功能和复杂结构与天然肌肉组织的相似性，从而潜在地增强肌肉组织再生并恢复肌肉功能。在本综述中，我们讨论了使用纳米生物材料和先进的纳米/微制造技术创建3D肌肉组织构建体及其再生能力的最新趋势。强调了当前的挑战和潜在解决方案，并讨论了该领域未来前景的影响和机遇，包括创建个性化和生物可制造平台的可能性。
