Department of Applied Chemistry, University of Yamanashi, 4-3-11 Takeda, Kofu, 400-8511, Japan.
Shinwa Chemical Industries Ltd., 50-2 Kagekatsu, Fushimi, Kyoto, 612-8307, Japan.
Anal Sci. 2024 Jan;40(1):3-8. doi: 10.1007/s44211-023-00449-8. Epub 2023 Oct 25.
An analytical method for quantifying the volatile anticancer drugs ifosfamide (IF) and cyclophosphamide (CP) in air was developed on the basis of thermal desorption (TD)-gas chromatography-mass spectrometry. Polydimethylsiloxane-coated macroporous silica was used as the adsorbent. The extraction tube was prepared by packing 0.2 g of adsorbent particles into a glass tube. The extraction and desorption efficiencies of the proposed method were quantitatively investigated in this study. The limits of detection of the proposed method for IF and CP were 3.3 ng L at an air sampling volume of 3.0 L (30 min). The sensitivity of the proposed method was compared with using a Tenax TA packed tube that is widely used as the extraction medium in TD analysis. Finally, detection of IF and CP that evaporated from aqueous standard solution was investigated.
建立了一种基于热解吸-气相色谱-质谱联用技术测定空气中挥发性抗癌药物异环磷酰胺（IF）和环磷酰胺（CP）的分析方法。采用聚二甲基硅氧烷涂覆的大孔硅胶作为吸附剂。提取管是通过将 0.2 g 吸附剂颗粒装入玻璃管中制备的。本研究定量研究了所提出方法的提取和解析效率。在所提出的方法中，IF 和 CP 的检测限分别为 3.3 ng L，空气采样体积为 3.0 L（30 min）。将所提出的方法的灵敏度与作为 TD 分析中常用的提取介质的 Tenax TA 填充管进行了比较。最后，考察了从水溶液标准溶液中蒸发的 IF 和 CP 的检测。
