口服大剂量硫胺素治疗静止期炎症性肠病和慢性疲劳患者的 B 族维生素、相关类似物和代谢物。
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
机构信息
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Bevital AS, Jonas Lies Veg 87, 5021, Bergen, Norway.
出版信息
Mol Med. 2023 Oct 25;29(1):143. doi: 10.1186/s10020-023-00741-3.
BACKGROUND
High doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) and chronic fatigue. In this study we analysed plasma samples obtained in a randomised clinical trial and aimed compare levels of vitamins B1, B2, B3 and B6, and their related vitamers and metabolites in patients with IBD, with or without chronic fatigue and with or without effect of high dose oral thiamine for chronic fatigue.
METHODS
Blood samples from patients with fatigue were drawn prior and after thiamine exposure and only once for patients without fatigue. A wide panel of analysis were done at Bevital AS Lab.
RESULTS
Concentration of flavin mononucleotide (FMN) was lower in patients with chronic fatigue compared to patients without fatigue (p = 0.02). Patients with chronic fatigue who reported a positive effect on fatigue after 4 weeks of high dose thiamine treatment had a statistically significantly lower level of riboflavin after thiamine treatment (p = 0.01).
CONCLUSION
FMN and Riboflavin were associated with chronic fatigue in patients with quiescent IBD. Levels of other B vitamins and metabolites were not significantly different between the investigated groups or related to effect of the thiamine intervention.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov study identifier NCT036347359. Registered 15 August 2018, https://clinicaltrials.gov/study/NCT03634735?cond=Inflammatory%20Bowel%20Diseases&intr=Thiamine&rank=1.
背景
大剂量口服硫胺素可改善静止期炎症性肠病（IBD）和慢性疲劳患者的临床疲劳评分。在这项研究中，我们分析了一项随机临床试验中获得的血浆样本，旨在比较有或无慢性疲劳以及有或无大剂量口服硫胺素治疗慢性疲劳效果的 IBD 患者的维生素 B1、B2、B3 和 B6 及其相关维生素和代谢物水平。
方法
疲劳患者在接受硫胺素暴露前后抽取血液样本，而无疲劳患者仅抽取一次。Bevital AS 实验室进行了广泛的分析。
结果
与无疲劳患者相比，慢性疲劳患者的黄素单核苷酸（FMN）浓度较低（p=0.02）。在接受 4 周大剂量硫胺素治疗后报告疲劳有阳性改善的慢性疲劳患者，在接受硫胺素治疗后，核黄素水平有统计学意义的降低（p=0.01）。
结论
FMN 和核黄素与静止期 IBD 患者的慢性疲劳有关。其他 B 族维生素和代谢物的水平在研究组之间没有显著差异，也与硫胺素干预的效果无关。
临床试验注册
ClinicalTrials.gov 研究标识符 NCT036347359。于 2018 年 8 月 15 日注册，https://clinicaltrials.gov/study/NCT036347359?cond=Inflammatory%Bowel%Diseases&intr=Thiamine&rank=1。
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