在瘤内注射内毒素和分枝杆菌硫脂的乳化混合物后，移植的豚鼠肝癌发生消退。
Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.
作者信息
Yarkoni E, Goren M B, Rapp H J
出版信息
Infect Immun. 1979 May;24(2):357-62. doi: 10.1128/iai.24.2.357-362.1979.
Abstract
Mycobacterial sulfatides (sulfolipids) in admixture with endotoxin had tumor regressive activity comparable to trehalose-6,6'-dimycolate (TDM) and endotoxin in guinea pigs, but unlike TDM were neither toxic nor granulomagenic and had no antitumor activity in mice. The increased endotoxin lethality in mice pretreated with BCG was not observed in mice pretreated with sulfolipids or TDM instead of BCG.
摘要
与内毒素混合的分枝杆菌硫脂（硫糖脂）在豚鼠体内具有与海藻糖-6,6'-二霉菌酸酯（TDM）和内毒素相当的肿瘤消退活性，但与TDM不同的是，它既无毒性也不致肉芽肿，并且在小鼠体内没有抗肿瘤活性。在用硫脂或TDM而非卡介苗预处理的小鼠中，未观察到在用卡介苗预处理的小鼠中出现的内毒素致死率增加的情况。
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