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在水介质中用灭活卡介苗细胞对豚鼠10号肝癌进行免疫治疗。

Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.

作者信息

Bekierkunst A, Goren M B

出版信息

Infect Immun. 1979 Jun;24(3):817-20. doi: 10.1128/iai.24.3.817-820.1979.

DOI:10.1128/iai.24.3.817-820.1979
PMID:381203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414380/
Abstract

Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose displayed a stronger tumor regressive activity and the process of healing was accelerated when endotoxin from a rough (Re) strain of Salmonella typhimurium was added to the BCG bacilli.

摘要

悬浮于1.5%羧甲基纤维素中的灭活卡介苗细胞在很大比例的病例中治愈了患有10号线肿瘤的豚鼠。卡介苗在羧甲基纤维素中的细菌制剂表现出更强的肿瘤消退活性，当将鼠伤寒沙门氏菌粗糙（Re）菌株的内毒素添加到卡介苗杆菌中时，愈合过程会加速。

相似文献

1
Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.在水介质中用灭活卡介苗细胞对豚鼠10号肝癌进行免疫治疗。
Infect Immun. 1979 Jun;24(3):817-20. doi: 10.1128/iai.24.3.817-820.1979.
2
Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.在瘤内注射内毒素和分枝杆菌硫脂的乳化混合物后，移植的豚鼠肝癌发生消退。
Infect Immun. 1979 May;24(2):357-62. doi: 10.1128/iai.24.2.357-362.1979.
3
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.用移植性肝癌对豚鼠进行免疫治疗：瘤内注射灭活卡介苗细胞与卡介苗细胞壁的比较
Infect Immun. 1979 Sep;25(3):1087-9. doi: 10.1128/iai.25.3.1087-1089.1979.
4
Tumor regression caused by endotoxins and mycobacterial fractions.内毒素和分枝杆菌成分引起的肿瘤消退。
J Natl Cancer Inst. 1975 Nov;55(5):1253-7. doi: 10.1093/jnci/55.5.1253.
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Immunotherapeutic trials of murine and guinea-pig solid tumors by oral administration of BCG.通过口服卡介苗对小鼠和豚鼠实体瘤进行免疫治疗试验。
Jpn J Med Sci Biol. 1979 Feb;32(1):1-18. doi: 10.7883/yoken1952.32.1.
6
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally injected emulsions containing heat-killed Nocardia rubra, Mycobacterium bovis (BCG) and Mycobacterium phlei.用移植性肝癌对豚鼠进行免疫治疗：对瘤内注射含有热灭活红色诺卡氏菌、牛型分枝杆菌（卡介苗）和草分枝杆菌的乳剂的比较。
Oncology. 1982;39(5):314-8. doi: 10.1159/000225659.
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Augmentation of immunity of line 10 hepatoma by BCG: comparison of different BCG preparations.卡介苗增强10号线肝癌免疫力：不同卡介苗制剂的比较
Cancer. 1980 Aug 1;46(3):488-96. doi: 10.1002/1097-0142(19800801)46:3<488::aid-cncr2820460312>3.0.co;2-m.
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Immunotherapy of guinea pigs with dermal and visceral tumor implants: comparison of living and nonliving BCG.用皮肤和内脏肿瘤植入物对豚鼠进行免疫治疗：活卡介苗与灭活卡介苗的比较
Infect Immun. 1979 May;24(2):565-66. doi: 10.1128/iai.24.2.565-566.1979.
9
Synergistic activity of components of mycobacteria and mutant Salmonella in causing regression of line-10 tumors in guinea pigs.分枝杆菌成分与突变沙门氏菌在使豚鼠10号线肿瘤消退方面的协同活性。
Cancer Res. 1979 May;39(5):1766-71.
10
Suppression and immunotherapy of the guinea pig line 10 hepatocarcinoma mediated by heat-killed disrupted Mycobacterium bovis strain Bacillus Calmette-Guérin.热灭活破碎的牛分枝杆菌卡介苗菌株介导的豚鼠10号线肝癌的抑制与免疫治疗
Cancer Res. 1980 Sep;40(9):3214-7.

引用本文的文献

1
Immunotherapeutic Agents for Intratumoral Immunotherapy.用于瘤内免疫治疗的免疫治疗药物。
Vaccines (Basel). 2023 Nov 14;11(11):1717. doi: 10.3390/vaccines11111717.

本文引用的文献

1
Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6'-Dimycolate) in Tumor Regression.非活卡介苗和分枝杆菌衍生成分的癌症免疫治疗：cord 因子（海藻糖-6,6'-二没食子酸酯）在肿瘤消退中的作用。
Infect Immun. 1974 Nov;10(5):1044-50. doi: 10.1128/iai.10.5.1044-1050.1974.
2
Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom).对香菇（一种食用菌）中具有显著抗肿瘤活性的多糖，尤其是香菇多糖进行分级分离和纯化。
Cancer Res. 1970 Nov;30(11):2776-81.
3
Endotoxin and double stranded RNA render macrophages cytotoxic.内毒素和双链RNA可使巨噬细胞具有细胞毒性。
Nat New Biol. 1971 Jul 21;232(29):76-8. doi: 10.1038/newbio232076a0.
4
Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。
J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.
5
Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.T淋巴细胞对丝裂原反应的增强作用。I. 反应细胞。
J Exp Med. 1972 Jul 1;136(1):128-42. doi: 10.1084/jem.136.1.128.
6
Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli.分枝杆菌组分和卡介苗杆菌诱导的小鼠足垫及引流淋巴结中的细胞反应。
Infect Immun. 1971 Sep;4(3):245-55. doi: 10.1128/iai.4.3.245-255.1971.
7
Effects of endotoxins on susceptibility to infections.内毒素对感染易感性的影响。
J Infect Dis. 1970 Sep;122(3):205-15. doi: 10.1093/infdis/122.3.205.
8
Molecular aspects of endotoxic reactions.内毒素反应的分子层面
Bacteriol Rev. 1969 Mar;33(1):72-98. doi: 10.1128/br.33.1.72-98.1969.
9
Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA.内毒素、脂多糖A和双链RNA抗肿瘤作用的相似性
Br J Cancer. 1973 May;27(5):370-89. doi: 10.1038/bjc.1973.45.
10
Effect of endotoxin on tumor resistance in mice.内毒素对小鼠肿瘤抵抗力的影响。
Infect Immun. 1974 Jan;9(1):95-100. doi: 10.1128/iai.9.1.95-100.1974.