Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Sci Rep. 2017 Jul 13;7(1):5357. doi: 10.1038/s41598-017-05575-8.
This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power. Applying OCT, PSP patients showed a smaller RNFL thickness in the inferior nasal and inferior temporal areas. The macular volume and the thickness of the majority of macular sectors were reduced compared to controls. SLP data showed a thinner RNFL thickness and an increase in the NFI in PSP patients. Sensitivity and specificity to discriminate PSP patients from controls were higher applying SLP than SD-OCT. Retinal changes did not correlate with disease duration or severity in any OCT or SLP measurement. PSP seems to be associated with reduced thickness and volume of the macula and reduction of the RNFL, independent of disease duration or severity. Retinal imaging with SD-OCT and SLP might become an additional tool in PSP diagnosis.
本横断面研究比较了进行性核上性麻痹（PSP）患者与健康对照者的视网膜形态。（通过谱域光相干断层扫描（SD-OCT）研究了 22 名 PSP 患者和 151 名对照者视盘周围的视网膜神经纤维层（RNFL）和黄斑区视网膜。此外，通过扫描激光偏振仪（SLP）测量了 RNFL 和神经纤维指数（NFI）。比较了 SD-OCT 和 SLP 的 RNFL 测量结果，以评估诊断的鉴别能力。应用 OCT，PSP 患者在下鼻侧和下颞侧的 RNFL 厚度较小。与对照组相比，黄斑体积和大多数黄斑区节段的厚度减小。SLP 数据显示 PSP 患者的 RNFL 厚度较薄，NFI 增加。与 SD-OCT 相比，应用 SLP 区分 PSP 患者和对照组的敏感性和特异性更高。任何 OCT 或 SLP 测量中，视网膜变化均与疾病持续时间或严重程度无关。PSP 似乎与黄斑厚度和体积减小以及 RNFL 减少有关，与疾病持续时间或严重程度无关。SD-OCT 和 SLP 的视网膜成像可能成为 PSP 诊断的附加工具。
