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间充质干/基质细胞衍生的小细胞外囊泡（MSC-sEVs）：糖尿病足溃疡的一种有前景的治疗方式。

Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer.

作者信息

Kouroupis Dimitrios, Kaplan Lee D, Ricordi Camillo, Best Thomas M

机构信息

Department of Orthopaedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, FL 33146, USA.

Diabetes Research Institute & Cell Transplant Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

出版信息

Bioengineering (Basel). 2023 Sep 28;10(10):1140. doi: 10.3390/bioengineering10101140.

DOI:10.3390/bioengineering10101140
PMID:37892870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10604677/
Abstract

Diabetic foot ulcer (DFU) is associated with neuropathy and/or peripheral artery disease of the lower limb in diabetic patients, affecting quality of life and leading to repeated hospitalizations and infections [...].

摘要

糖尿病足溃疡（DFU）与糖尿病患者的下肢神经病变和/或外周动脉疾病相关，影响生活质量，并导致反复住院和感染[...]。

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Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer.间充质干/基质细胞衍生的小细胞外囊泡（MSC-sEVs）：糖尿病足溃疡的一种有前景的治疗方式。
Bioengineering (Basel). 2023 Sep 28;10(10):1140. doi: 10.3390/bioengineering10101140.
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本文引用的文献

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CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions.CD10 结合的人源间充质干细胞/基质细胞衍生的小细胞外囊泡具有免疫调节作用，并在炎症条件下维持软骨稳态。
Cells. 2023 Jul 11;12(14):1824. doi: 10.3390/cells12141824.
2
Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches.基于细胞外囊泡的生物载体在慢性伤口愈合中的作用：生物发生与递送方法
Mol Ther Nucleic Acids. 2023 May 9;32:822-840. doi: 10.1016/j.omtn.2023.05.002. eCollection 2023 Jun 13.
3
Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight.间充质干细胞疗法治疗不愈合的糖尿病足溃疡感染：新见解。
Front Bioeng Biotechnol. 2023 Apr 13;11:1158484. doi: 10.3389/fbioe.2023.1158484. eCollection 2023.
4
CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes.CD146+ 子宫内膜来源的间充质干细胞亚群具有具有强烈免疫调节 miRNA 特性的细胞外囊泡分泌组。
Cells. 2022 Dec 10;11(24):4002. doi: 10.3390/cells11244002.
5
Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing.干细胞与血管生成：在促进慢性糖尿病足溃疡愈合方面的意义和局限性。
Cells. 2022 Jul 25;11(15):2287. doi: 10.3390/cells11152287.
6
Mechanism and application of exosomes in the wound healing process in diabetes mellitus.外泌体在糖尿病创面愈合过程中的作用机制及其应用。
Diabetes Res Clin Pract. 2022 May;187:109882. doi: 10.1016/j.diabres.2022.109882. Epub 2022 Apr 26.
7
Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures.人髌下脂肪垫间充质干细胞具有免疫调节的外泌体特征。
Sci Rep. 2022 Mar 4;12(1):3609. doi: 10.1038/s41598-022-07569-7.
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Aging Cell. 2021 Apr;20(4):e13337. doi: 10.1111/acel.13337. Epub 2021 Mar 16.
9
Diagnosis of infection in the foot in diabetes: a systematic review.糖尿病足感染的诊断：系统评价。
Diabetes Metab Res Rev. 2020 Mar;36 Suppl 1:e3281. doi: 10.1002/dmrr.3281.
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Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation.髌下脂肪垫来源间充质干细胞对炎症和纤维化的反应诱导一种免疫调节表型，涉及 CD10 介导的 P 物质降解。
Sci Rep. 2019 Jul 26;9(1):10864. doi: 10.1038/s41598-019-47391-2.