Department of Obstetrics and Gynecology, University of Medicine Pharmacy Science and Technology George Emil Palade of Târgu Mures, 540142 Târgu Mures, Romania.
Department of Neonatology, University of Rochester Medical Center Golisano Children's Hospital at Strong, Rochester, NY 14642, USA.
Medicina (Kaunas). 2023 Oct 4;59(10):1768. doi: 10.3390/medicina59101768.
: We investigated the effect of optimal maternal glycemic control on neonatal outcomes among infants born to mothers with diabetes. : In this prospective study, we assessed 88 eligible mothers admitted to the obstetrics department for pregnancy evaluation. Our analysis included 46 infants born to diabetic mothers (IDMs) and 138 infants born to unaffected mothers, all admitted to the Level II Neonatal Intensive Care Unit (NICU). : Mothers affected by diabetes were generally older and exhibited a higher body mass index (BMI) and a greater number of gestations, although parity did not differ significantly. Cesarean section emerged as the most frequently chosen mode of delivery. A significantly higher proportion of infants in the affected group presented with respiratory disease (3% vs. 19.5%), which required NICU admission (4.3% vs. 23.9%), phototherapy (18.1% vs. 43.5%), and had congenital heart defects or myocardial hypertrophy (15.2% and 26% vs. 3% and 4.3%) compared to matched controls ( < 0.05). : This study underscores the persistence of adverse neonatal outcomes in IDMs, even when maternal glycemic control is optimized. It calls for further investigation into potential interventions and strategies aimed at enhancing neonatal outcomes in this population.
我们研究了母亲血糖控制最佳对糖尿病母亲所生婴儿的新生儿结局的影响。
在这项前瞻性研究中，我们评估了 88 名因妊娠评估而入住妇产科的合格母亲。我们的分析包括 46 名糖尿病母亲所生婴儿（IDM）和 138 名未受影响母亲所生婴儿，均入住二级新生儿重症监护病房（NICU）。
患有糖尿病的母亲通常年龄较大，体重指数（BMI）较高，妊娠次数较多，但产次无显著差异。剖宫产是最常选择的分娩方式。受影响组中患有呼吸疾病的婴儿比例显著较高（3%对 19.5%），需要入住 NICU（4.3%对 23.9%）、光疗（18.1%对 43.5%），且患有先天性心脏病或心肌肥厚（15.2%和 26%对 3%和 4.3%）的比例明显高于匹配对照组（<0.05）。
本研究强调了即使优化了母亲的血糖控制，IDM 仍存在不良新生儿结局，需要进一步研究针对该人群的潜在干预措施和策略，以改善新生儿结局。
