Chestnut D H, Weiner C P, Martin J G, Herrig J E, Wang J P
Anesthesiology. 1986 Dec;65(6):633-6. doi: 10.1097/00000542-198612000-00011.
The purpose of the present study was to determine the effect of intravenously administered epinephrine on the maternal cardiovascular response and uterine artery blood flow velocity (UBFV) in the pregnant guinea pig. Epinephrine (0.2, 0.5, and 1.0 micrograms/kg) and lidocaine (0.4 mg/kg, with and without 0.2 micrograms/kg of epinephrine) were administered intravenously to seven chronically instrumented pregnant guinea pigs near term. Lidocaine without epinephrine did not significantly alter maternal heart rate (MHR), maternal mean arterial pressure (MMAP), or UBFV. Epinephrine, with and without lidocaine, resulted in a transient decrease in MHR. Further, epinephrine, with and without lidocaine, resulted in significant elevations in MMAP and significant, dose-related reductions in UBFV. Mean (+/- SEM) UBFV was 72 +/- 4%, 56 +/- 4%, and 40 +/- 5% of baseline at 30 s after administration of epinephrine, 0.2, 0.5, and 1.0 micrograms/kg, respectively. It is concluded that these small intravenous boluses of epinephrine result in significant, although transient, reductions in UBFV in the pregnant guinea pig.
本研究的目的是确定静脉注射肾上腺素对妊娠豚鼠母体心血管反应及子宫动脉血流速度（UBFV）的影响。对7只近足月的慢性仪器植入妊娠豚鼠静脉注射肾上腺素（0.2、0.5和1.0微克/千克）和利多卡因（0.4毫克/千克，加或不加0.2微克/千克肾上腺素）。不含肾上腺素的利多卡因对母体心率（MHR）、母体平均动脉压（MMAP）或UBFV无显著影响。含或不含利多卡因的肾上腺素均导致MHR短暂下降。此外，含或不含利多卡因的肾上腺素均导致MMAP显著升高，以及UBFV显著降低且呈剂量相关。静脉注射肾上腺素0.2、0.5和1.0微克/千克后30秒，平均（±SEM）UBFV分别为基线的72±4%、56±4%和40±5%。结论是，这些小剂量静脉注射肾上腺素虽为短暂性，但会导致妊娠豚鼠的UBFV显著降低。
