Dain S L, Rolbin S H, Hew E M
Department of Anaesthesia, Mount Sinai Hospital, University of Toronto, Ontario.
Can J Anaesth. 1987 Nov;34(6):601-5. doi: 10.1007/BF03010519.
One must distinguish between what is medically safe and what is legally safe. The authors have the impression that in order to be "legally safe" one must perform a test dose. This is despite the fact that it has not been conclusively shown that the use of test doses improve the safety margin of epidural anaesthesia, when administered by a competent person, with the proper resuscitative equipment immediately available. Until a controlled study is performed, test doses should be done for continuous epidural anaesthesia with the understanding that they are neither 100 per cent sensitive nor specific in preventing complications. It is however one more manoeuvre that may be useful in recognizing some of the patients with accidental subarachnoid placement of epidural catheters. The literature suggests that lidocaine 1.5 per cent in dextrose 7.5 per cent should be the test dose of choice in obstetric epidural anaesthesia in an amount known to produce spinal anaesthesia (30-50 mg). The use of epinephrine in test doses in unpremedicated healthy women in active labour is neither sensitive nor specific in signalling intravascular injection, and it may also be detrimental to fetal wellbeing. Epinephrine 15 micrograms as a test dose for intravenous injection appears to create more problems than it solves.
必须区分医学上的安全和法律上的安全。作者们感觉,为了“法律上的安全”,必须给予试验剂量。尽管事实上,当由胜任的人员在有合适的复苏设备立即可用时给予试验剂量时,尚未确凿表明其能提高硬膜外麻醉的安全界限。在进行对照研究之前,对于连续硬膜外麻醉应给予试验剂量,但要明白它们在预防并发症方面既不是100%敏感也不是100%特异的。然而,这是一种可能有助于识别一些硬膜外导管意外误置入蛛网膜下腔患者的操作。文献表明,1.5%利多卡因加7.5%葡萄糖应作为产科硬膜外麻醉试验剂量的首选,其剂量已知可产生脊髓麻醉(30 - 50毫克)。在未用药的活跃期健康产妇中,将肾上腺素用于试验剂量来提示血管内注射既不敏感也不特异,而且可能对胎儿健康有害。15微克肾上腺素作为静脉注射的试验剂量似乎产生的问题比解决的问题更多。