Yang Muyue, Yang Zhen, Wang Pu, Sun Zhihui
Shanghai Jiao Tong University, Shanghai, China.
Core Facility of West China Hospital, Chengdu, Sichuan Province, China.
Neural Regen Res. 2021 Jun;16(6):1177-1185. doi: 10.4103/1673-5374.300486.
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions. Photobiomodulation can promote neurogenesis and elicit anti-apoptotic, anti-inflammatory and antioxidative responses. Its therapeutic effects have been demonstrated in studies on neurological diseases, peripheral nerve injuries, pain relief and wound healing. We conducted a comprehensive literature review of the application of photobiomodulation in patients with central nervous system diseases in February 2019. The NCBI PubMed database, EMBASE database, Cochrane Library and ScienceDirect database were searched. We reviewed 95 papers and analyzed. Photobiomodulation has wide applicability in the treatment of stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease, major depressive disorder, and other diseases. Our analysis provides preliminary evidence that PBM is an effective therapeutic tool for the treatment of central nervous system diseases. However, additional studies with adequate sample size are needed to optimize treatment parameters.
使用红光或近红外光区域的光进行光生物调节是一种针对多种神经和心理疾病的创新治疗策略。光生物调节可促进神经发生，并引发抗凋亡、抗炎和抗氧化反应。其治疗效果已在神经疾病、周围神经损伤、疼痛缓解和伤口愈合的研究中得到证实。2019年2月，我们对光生物调节在中枢神经系统疾病患者中的应用进行了全面的文献综述。检索了NCBI PubMed数据库、EMBASE数据库、Cochrane图书馆和ScienceDirect数据库。我们审查并分析了95篇论文。光生物调节在中风、创伤性脑损伤、帕金森病、阿尔茨海默病、重度抑郁症和其他疾病的治疗中具有广泛的适用性。我们的分析提供了初步证据，表明光生物调节是治疗中枢神经系统疾病的有效治疗工具。然而，需要更多具有足够样本量的研究来优化治疗参数。
