调整TiN-Ag修饰的SLA-Ti上银离子植入剂量可产生不同的微米纳米结构：对牙种植体抑菌、生物相容性和成骨的影响

Adjusting the Dose of Ag-Ion Implantation on TiN-Ag-Modified SLA-Ti Creates Different Micronanostructures: Implications on Bacteriostasis, Biocompatibility, and Osteogenesis in Dental Implants.

作者信息

Ma Ming, Zhao Mengli, Ji Ruotong, Guo Yi, Li Dejun, Zeng Sujuan

机构信息

Department of Pediatric dentistry, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong 510182, China.

School of Electronic Engineering, Chaohu University, Anhui 238024, China.

出版信息

ACS Omega. 2023 Oct 12;8(42):39269-39278. doi: 10.1021/acsomega.3c04769. eCollection 2023 Oct 24.

DOI:10.1021/acsomega.3c04769

PMID:37901550

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10601048/

Abstract

The prevention of aseptic loosening and peri-implantitis is crucial for the success of dental implant surgery. In this study, different doses of Ag-implanted TiN/Ag nanomultilayers were prepared on the sandblasting with large grit and acid etching (SLA)-Ti surface using a multiarc ion-plating system and an ion-implantation system, respectively. The physical and chemical properties of the samples were assessed using various techniques, including scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, atomic force microscopy, inductively coupled plasma atomic emission spectrometry, and water contact angle measurements. In addition, the applicability and biosafety of the SLA/1 × 10-Ag and SLA/1 × 10-Ag surfaces were determined via biocompatibility testing in vivo and in vitro. The results demonstrated that the physical and chemical properties of SLA/1 × 10-Ag and SLA/1 × 10-Ag surfaces were different to some extent. However, compared with SLA-Ti, silver-loaded TiN/Ag-modified SLA-Ti surfaces (SLA/1 × 10-Ag) with enhanced bacteriostatis, osteogenesis, and biocompatibility have great potential for dental applications.

摘要

预防无菌性松动和种植体周围炎对于牙种植手术的成功至关重要。在本研究中，分别使用多弧离子镀系统和离子注入系统，在大颗粒喷砂和酸蚀（SLA）钛表面制备了不同剂量银植入的TiN/Ag纳米多层膜。使用多种技术评估样品的物理和化学性质，包括扫描电子显微镜、能量色散光谱、X射线衍射、X射线光电子能谱、原子力显微镜、电感耦合等离子体原子发射光谱法和水接触角测量。此外，通过体内和体外生物相容性测试确定SLA/1×10⁻⁶Ag和SLA/1×10⁻⁸Ag表面的适用性和生物安全性。结果表明，SLA/1×10⁻⁶Ag和SLA/1×10⁻⁸Ag表面的物理和化学性质在一定程度上有所不同。然而，与SLA钛相比，负载银的TiN/Ag修饰的SLA钛表面（SLA/1×10⁻⁶Ag）具有增强的抑菌、成骨和生物相容性，在牙科应用中具有巨大潜力。