Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Clin Exp Hypertens. 2023 Dec 31;45(1):2272581. doi: 10.1080/10641963.2023.2272581. Epub 2023 Oct 30.
The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension.
A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The Cox proportional hazard ratios were used to evaluate the association between the TyG index and the risk of mortality.
Over a follow-up period of 7.87 years, 991 all-cause death and 189 cardiovascular deaths occurred. Compared with the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals were 1.28 (1.07-1.53; = .006) in the fourth quartile for all-cause mortality and 0.63 (0.42-0.96; = .031) in the second quartile for cardiovascular mortality. Dose-response analysis indicated an L-shaped relationship.
The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.
甘油三酯和葡萄糖（TyG）指数与更高的死亡率显著相关。然而，缺乏研究探索 TyG 指数与高血压中老年人群全因和心血管死亡率之间的具体关系。
共纳入来自全国健康和营养检查调查的 3614 名高血压患者。TyG 指数通过公式 log[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]计算。使用 Cox 比例风险比评估 TyG 指数与死亡率风险之间的关系。
在 7.87 年的随访期间，发生了 991 例全因死亡和 189 例心血管死亡。与参考四分位相比，全因死亡率的多变量校正风险比和 95%置信区间在第四四分位为 1.28（1.07-1.53）；=0.006），心血管死亡率的第二四分位为 0.63（0.42-0.96）；=0.031）。剂量反应分析表明存在 L 形关系。
TyG 指数与高血压中老年人群全因死亡率呈 L 形关联。
