Gonciarz Z, Checińska J, Cholewka A, Staszalek K, Garstka E
Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):622-4.
Concentrations of penicillin-G produced in serum by either direct intraduodenal (i.d.) or intramuscular (i.m.) administration were compared in 9 healthy volunteers. Serum specimens were assayed by the Sarcina lutea cup plate method. The peak serum levels achieved by i.d. application were similar to those observed after intramuscular dose. However, higher concentrations were better sustained after i.m. penicillin. We concluded that intraduodenal administration of penicillin-G could be considered as an alternative for i.m. injection.
在9名健康志愿者中比较了通过直接十二指肠内（i.d.）或肌肉内（i.m.）给药在血清中产生的青霉素G浓度。血清标本采用藤黄八叠球菌杯碟法进行测定。十二指肠内给药达到的血清峰值水平与肌肉注射后观察到的水平相似。然而，肌肉注射青霉素后较高的浓度能更好地维持。我们得出结论，十二指肠内给予青霉素G可被视为肌肉注射的一种替代方法。
