甘油三酯-葡萄糖指数与前列腺癌风险的关联：一项回顾性研究。
Association of triglyceride-glucose index with the risk of prostate cancer: a retrospective study.
机构信息
School of Public Health, Xinjiang Medical University, Urumqi, China.
School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
出版信息
PeerJ. 2023 Nov 7;11:e16313. doi: 10.7717/peerj.16313. eCollection 2023.
BACKGROUND
Prostate cancer is the most common malignancy in men, and its incidence is increasing year by year. Some studies have shown that risk factors for prostate cancer are related to insulin resistance. The triglyceride-glucose (TyG) index is a marker of insulin resistance. We investigated the validity of TyG index for predicting prostate cancer and the dose-response relationship in prostate cancer in relation to it.
OBJECTIVE
To investigate the risk factors of TyG index and prostate cancer prevalence.
METHODS
This study was screened from the First Affiliated Hospital of Xinjiang Medical University and included 767 people, including 136 prostate cancer patients in the case group and 631 healthy people in the control group. The relationship between TyG index and the risk of prostate cancer was analyzed by one-way logistic regression, adjusted for relevant factors, and multi-factor logistic regression analysis was performed to further investigate the risk factors affecting the prevalence of prostate cancer. ROC curves and Restricted Cubic Spline were established to determine the predictive value and dose-response relationship of TyG index in prostate cancer.
RESULTS
Blood potassium (OR = 0.056, 95% CI [0.021-0.148]), total cholesterol (OR = 1.07, 95% CI [0.792-1.444]) and education level (OR = 0.842, 95% CI [0.418-1.697]) were protective factors for prostate cancer, alkaline phosphatase, age, LDL, increased the risk of prostate cancer (OR = 1.016, 95% CI [1.006-1.026]) (OR = 139.253, 95% CI [18.523-1,046.893] (OR = 0.318, 95% CI [0.169-0.596]); TyG index also was a risk factor for prostate cancer, the risk increased with TyG levels,and persons in the TyGQ3 group (8.373-8.854 mg/dL) was 6.918 times (95% CI [2.275-21.043]) higher than in the Q1 group,in the TyGQ4 group (≥8.854) was 28.867 times of those in the Q1 group (95% CI [9.499-87.727]).
CONCLUSION
TyG index may be a more accurate and efficient predictor of prostate cancer.
背景
前列腺癌是男性最常见的恶性肿瘤，其发病率呈逐年上升趋势。一些研究表明，前列腺癌的危险因素与胰岛素抵抗有关。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的标志物。我们研究了 TyG 指数对前列腺癌的预测价值及其与前列腺癌的剂量反应关系。
目的
探讨 TyG 指数与前列腺癌患病率的关系。
方法
本研究从新疆医科大学第一附属医院筛选，共纳入 767 人，其中病例组 136 例前列腺癌患者，对照组 631 例健康人。采用单因素 logistic 回归分析 TyG 指数与前列腺癌的关系，经相关因素校正后，采用多因素 logistic 回归分析影响前列腺癌患病率的危险因素。绘制 ROC 曲线和受限立方样条，确定 TyG 指数对前列腺癌的预测价值和剂量反应关系。
结果
血钾（OR=0.056，95%CI [0.021-0.148]）、总胆固醇（OR=1.07，95%CI [0.792-1.444]）和教育程度（OR=0.842，95%CI [0.418-1.697]）是前列腺癌的保护因素，碱性磷酸酶、年龄、LDL 则增加前列腺癌的发病风险（OR=1.016，95%CI [1.006-1.026]）（OR=139.253，95%CI [18.523-1046.893]）（OR=0.318，95%CI [0.169-0.596]）；TyG 指数也是前列腺癌的危险因素，随着 TyG 水平的升高，患病风险增加，TyGQ3 组（8.373-8.854mg/dL）患病风险是 TyGQ1 组的 6.918 倍（95%CI [2.275-21.043]），TyGQ4 组（≥8.854）是 TyGQ1 组的 28.867 倍（95%CI [9.499-87.727]）。
结论
TyG 指数可能是前列腺癌更准确、更有效的预测指标。
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