Saedi Sedigheh, Noroozi Mona, Khosrotabar Naghmeh, Mazandarani Shadi, Ghadrdoost Behshid
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2017 Jan 15;31:5. doi: 10.18869/mjiri.31.5. eCollection 2017.
Restricted intakes of saturated and trans-fatty acids and replacement with poly or monounsaturated fatty acids are emphasized in healthy diets. This study evaluates the effects of a six-month consumption of canola oil compared to sunflower oil on lipid profile and anthropometric parameters of people affected by dyslipidemia. This randomized controlled trial was conducted on 96 patients with dyslipidemia, who were randomly assigned into canola oil or the sunflower oil groups. The participants were instructed to record the contents of their daily meals, beverages, fruits, and snacks a day before treatment, at the second clinic visit, in the third month, and at the end of study (i.e., six months). Lipid profile and anthropometric parameters were compared between the two groups. Student t-test or Mann Whitney U test was used for statistical comparisons of variables between groups. Multivariate analysis was performed to adjust the confounding factor effects. Of the enrolled participants, 44 (45.8%) were on sunflower oil diet and 52 (54.2%) on canola oil diet. We observed no change in anthropometric parameters and thus no significant difference between the two groups (p>0.05). Significant reductions in LDL-C (p<0.001), total cholesterol (p<0.001) and triglyceride levels (p<0.001), and significant elevation in HDL-C (p=0.008) were observed in canola oil group, as well as those who used sunflower oil. Dietary fats in the form of canola oil or sunflower oil effectively lower the serum cholesterol, LDL-C and triglyceride concentrations. They also result in an increase in serum concentration of HDL-C. These oils, however, did not modify general anthropometric parameters.
健康饮食强调限制饱和脂肪酸和反式脂肪酸的摄入,并用多不饱和脂肪酸或单不饱和脂肪酸替代。本研究评估了与葵花籽油相比,食用六个月菜籽油对血脂异常患者血脂谱和人体测量参数的影响。这项随机对照试验对96名血脂异常患者进行,他们被随机分为菜籽油组或葵花籽油组。参与者被要求在治疗前一天、第二次门诊就诊时、第三个月以及研究结束时(即六个月时)记录他们每日膳食、饮料、水果和零食的内容。比较两组的血脂谱和人体测量参数。使用学生t检验或曼-惠特尼U检验对组间变量进行统计学比较。进行多变量分析以调整混杂因素的影响。在纳入的参与者中,44人(45.8%)采用葵花籽油饮食,52人(54.2%)采用菜籽油饮食。我们观察到人体测量参数没有变化,因此两组之间没有显著差异(p>0.05)。在菜籽油组以及食用葵花籽油的人群中,均观察到低密度脂蛋白胆固醇(LDL-C)(p<0.001)、总胆固醇(p<0.001)和甘油三酯水平显著降低(p<0.001),高密度脂蛋白胆固醇(HDL-C)显著升高(p=0.008)。菜籽油或葵花籽油形式的膳食脂肪可有效降低血清胆固醇、LDL-C和甘油三酯浓度。它们还会导致血清HDL-C浓度升高。然而,这些油并没有改变一般人体测量参数。