吡咯并吡咯烯U，一种源自海绵共生真菌sp. SCSIO41420的新生物碱。
Pyripyropene U, a new alkaloid from the sponge-derived fungus sp. SCSIO41420.
作者信息
Chen Zhu, She Jianglian, Liu Juan, Peng Bo, Yuan Zhimin, Zhou Xuefeng
机构信息
Guangdong Ocean Association, Guangzhou, China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
出版信息
Nat Prod Res. 2025 Apr;39(7):1939-1944. doi: 10.1080/14786419.2023.2284866. Epub 2023 Nov 22.
One new alkaloid, named pyripyropene U (), and six known natural products (-) were obtained from the marine sponge-derived fungus sp. SCSIO41420. Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses, while the absolute configurations of the new compound were unambiguously confirmed by theoretical electronic circular dichroism (ECD) calculation. Those natural products were evaluated in the antimicrobial tests against various fungi and bacteria, and possessed obvious inhibitory activity against ATCC 29213.
从海洋海绵来源的真菌Pyripyropene U（）中获得了一种新的生物碱，命名为吡咯并吡咯烯U（），以及六种已知的天然产物（-）。通过详细的核磁共振（NMR）和质谱（MS）分析确定了它们的结构，而新化合物的绝对构型通过理论电子圆二色性（ECD）计算得到明确确认。对这些天然产物进行了针对各种真菌和细菌的抗菌测试评估，它们对ATCC 29213具有明显的抑制活性。
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