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药物输送的材料和设计工具包:现状、趋势和挑战。

Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges.

机构信息

Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey.

SUNUM Nanotechnology Research and Application Centre, Sabanci University, Istanbul 34956, Turkey.

出版信息

ACS Appl Mater Interfaces. 2023 Dec 6;15(48):55201-55231. doi: 10.1021/acsami.3c10065. Epub 2023 Nov 23.

Abstract

The nanomaterial and related toolkit have promising applications for improving human health and well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted and controlled manner, and they have shown potential to address issues associated with conventional drug delivery systems. They offer benefits for treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, and immunotherapeutic agents. The potential applications of this technology are vast; however, significant challenges exist to overcome such as safety issues, toxicity, efficacy, and insufficient capacity. This article discusses the latest developments in drug delivery systems, including drug release mechanisms, material toolkits, related design molecules, and parameters. The concluding section examines the limitations and provides insights into future possibilities.

摘要

该纳米材料和相关工具包在改善人类健康和福祉方面具有广阔的应用前景。基于纳米的药物传递系统使用纳米级材料作为载体,以靶向和控制的方式传递治疗剂,并且已经显示出解决与传统药物传递系统相关问题的潜力。它们通过封装或缀合生物制剂、化疗药物和免疫治疗药物,为治疗各种疾病提供了益处。这项技术的潜在应用非常广泛;然而,仍然存在一些重大挑战需要克服,如安全性问题、毒性、疗效和不足的能力。本文讨论了药物传递系统的最新发展,包括药物释放机制、材料工具包、相关设计分子和参数。最后一节检查了局限性,并对未来的可能性进行了探讨。

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