Center for Perinatal, Pediatric, and Environmental Epidemiology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Department of Pediatrics, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan.
BMC Pediatr. 2023 Nov 23;23(1):595. doi: 10.1186/s12887-023-04412-4.
This investigation assessed the impact of dog and/or cat ownership during infancy on the presence of functional constipation (FC) at 3 years of age.
The fixed data of 73,936 singleton births from a large national birth cohort study commencing in 2011 were used to identify FC as estimated by Rome III at 3 years of age. Multiple logistic regression analysis was employed to search for correlations between FC development and dog and/or cat ownership in early childhood.
A total of 8,459 toddlers (11.6%) met the Rome III criteria for FC at 3 years of age. Overall, 57,264 (77.5%) participants had never owned a dog or cat. We identified 7,715 (10.4%) infant-period owners, 1,295 (1.8%) current owners, and 7,762 (10.5%) long-term owners. Multivariate analysis showed that infant-period ownership remained significantly associated with the risk of developing FC at 3 years of age after adjusting for covariates (adjusted OR [95% CI] 1.09 [1.01-1.19] based on non-ownership).
This Japanese large nationwide survey uncovered a possible adverse effect of infant-period dog and/or cat ownership prior to 6 months of age on FC status at 3 years of age.
本研究旨在评估婴儿期拥有狗和/或猫对 3 岁时功能性便秘（FC）发生的影响。
本研究使用了一项始于 2011 年的大型全国性出生队列研究的固定数据，确定了 3 岁时符合罗马 III 标准的 FC。采用多因素逻辑回归分析，寻找 FC 发展与儿童早期狗和/或猫拥有之间的相关性。
共有 8459 名幼儿（11.6%）在 3 岁时符合罗马 III 标准的 FC 诊断。总体而言，57264 名（77.5%）参与者从未养过狗或猫。我们确定了 7715 名（10.4%）婴儿期所有者、1295 名（1.8%）当前所有者和 7762 名（10.5%）长期所有者。多变量分析显示，在调整了协变量后，婴儿期拥有与 3 岁时发生 FC 的风险仍然显著相关（非拥有者的调整优势比[95%可信区间]为 1.09[1.01-1.19]）。
这项日本全国性大规模调查揭示了婴儿期（6 个月前）拥有狗和/或猫可能对 3 岁时 FC 状况产生不利影响。
