International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
Small Methods. 2024 Mar;8(3):e2301332. doi: 10.1002/smtd.202301332. Epub 2023 Nov 23.
Chirality is a fundamental characteristic of living organisms and is commonly observed at the biomolecule, cellular, and tissue levels. Chiral nanomaterials play an irreplaceable role in nanomedicine and nanobiology because of their unique enantioselectivity with biological components. Here, research progress relating to chiral nanomaterials in the field of vaccines is reviewed, including antigen presenting systems, immune adjuvants, and cancer vaccines. First, the common synthesis methods are outlined for different types of chiral nanomaterials, as well as their chiral sources, optical properties, and potential biological applications. Then, the application of chiral nanomaterials are discussed in the field of vaccines with reference to the promotion of antigen presentation and activation of the immune system for tumor immunotherapy. Finally, the current obstacles and future research directions of chiral nanomaterials are revealed with regard to regulating the immune system.
手性是生命的基本特征，在生物分子、细胞和组织水平上普遍存在。手性纳米材料由于其与生物成分的独特对映选择性，在手性纳米医学和纳米生物学中发挥着不可替代的作用。本文综述了手性纳米材料在疫苗领域的研究进展，包括抗原呈递系统、免疫佐剂和癌症疫苗。首先，概述了不同类型手性纳米材料的常见合成方法，以及它们的手性来源、光学性质和潜在的生物学应用。然后，结合肿瘤免疫治疗中促进抗原呈递和激活免疫系统的内容，讨论了手性纳米材料在疫苗领域的应用。最后，揭示了手性纳米材料在调节免疫系统方面的当前障碍和未来研究方向。
