Department of Biomedical Sciences, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.
Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea.
Int J Mol Sci. 2021 Nov 19;22(22):12510. doi: 10.3390/ijms222212510.
Immunotherapy has been investigated for decades, and it has provided promising results in preclinical studies. The most important issue that hinders researchers from advancing to clinical studies is the delivery system for immunotherapy agents, such as antigens, adjuvants and agonists, and the activation of these agents at the tumour site. Polymers are among the most versatile materials for a variety of treatments and diagnostics, and some polymers are reactive to either endogenous or exogenous stimuli. Utilizing this advantage, researchers have been developing novel and effective polymeric nanomaterials that can deliver immunotherapeutic moieties. In this review, we summarized recent works on stimuli-responsive polymeric nanomaterials that deliver antigens, adjuvants and agonists to tumours for immunotherapy purposes.
免疫疗法已经研究了几十年，并且在临床前研究中取得了有希望的结果。阻碍研究人员进行临床研究的最重要问题是免疫治疗剂的输送系统，例如抗原、佐剂和激动剂，以及这些剂在肿瘤部位的激活。聚合物是用于各种治疗和诊断的最通用的材料之一，并且一些聚合物对内源性或外源性刺激有反应。利用这一优势，研究人员一直在开发新型有效的聚合物纳米材料，这些材料可以输送免疫治疗部分。在这篇综述中，我们总结了最近关于刺激响应性聚合物纳米材料的研究工作，这些材料将抗原、佐剂和激动剂递送到肿瘤部位以进行免疫治疗。
