Moriuchi J, Ichikawa Y, Takaya M, Shimizu H, Uchiyama M, Sato K, Tsuji K, Arimori S
Arthritis Rheum. 1986 Dec;29(12):1518-21. doi: 10.1002/art.1780291215.
Japanese patients with primary Sjögren's syndrome (SS), patients with SS and rheumatoid arthritis (SS-RA), and patients with SS and connective tissue disease without RA (nonrheumatoid connective tissue disease [SS-CTD]) were typed for HLA antigens. Patients with primary SS and those with SS-RA had higher frequencies of DRw53 than did those who had SS-CTD; however, the group with SS-CTD showed a negative correlation with DRw52. These data indicate that Japanese and white patients with SS have different HLA specificities, and that genetic factors involved in the development of SS-CTD might be different from those in primary SS and SS-RA.
对日本原发性干燥综合征（SS）患者、干燥综合征合并类风湿关节炎（SS-RA）患者以及干燥综合征合并无类风湿关节炎的结缔组织病（非类风湿性结缔组织病[SS-CTD]）患者进行了HLA抗原分型。原发性SS患者和SS-RA患者的DRw53频率高于SS-CTD患者；然而，SS-CTD组与DRw52呈负相关。这些数据表明，日本和白人SS患者具有不同的HLA特异性，并且参与SS-CTD发生发展的遗传因素可能与原发性SS和SS-RA中的遗传因素不同。
