Sandford Ryan, Yadav Ruchi, Noble Emma K, Sumner Kelsey, Joshi Devyani, Tartof Sara Y, Wernli Karen J, Martin Emily T, Gaglani Manjusha, Zimmerman Richard K, Talbot H Keipp, Grijalva Carlos G, Belongia Edward A, Carlson Christina, Coughlin Melissa, Flannery Brendan, Pearce Brad, Rogier Eric
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
medRxiv. 2023 Nov 18:2023.11.17.23298700. doi: 10.1101/2023.11.17.23298700.
To describe humoral immune responses to symptomatic SARS-CoV-2 infection, we assessed immunoglobulin G binding antibody levels using a commercial multiplex bead assay against SARS-CoV-2 ancestral spike protein receptor binding domain (RBD) and nucleocapsid protein (N). We measured binding antibody units per mL (BAU/mL) during acute illness within 5 days of illness onset and during convalescence in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 infection with Omicron variant viruses. Comparing acute- to convalescent phase antibody concentrations, geometric mean anti-N antibody concentrations increased 47-fold from 5.5 to 259 BAU/mL. Anti-RBD antibody concentrations increased 2.5-fold from 1258 to 3189 BAU/mL.
为了描述对有症状的SARS-CoV-2感染的体液免疫反应，我们使用针对SARS-CoV-2原始刺突蛋白受体结合域（RBD）和核衣壳蛋白（N）的商业多重珠分析来评估免疫球蛋白G结合抗体水平。我们在105例实验室确诊感染奥密克戎变异株病毒的门诊SARS-CoV-2感染患者的急性疾病期（发病后5天内）和恢复期测量了每毫升的结合抗体单位（BAU/mL）。比较急性期和恢复期的抗体浓度，抗N抗体的几何平均浓度从5.5 BAU/mL增加到259 BAU/mL，增长了47倍。抗RBD抗体浓度从1258 BAU/mL增加到3189 BAU/mL，增长了2.5倍。
