Cohen A B, Batra G, Petersen R, Podany J, Nguyen D
J Appl Physiol Respir Environ Exerc Physiol. 1979 Aug;47(2):440-4. doi: 10.1152/jappl.1979.47.2.440.
Morphometric methods and two unique characteristics of neutrophils enabled us to measure the size of the pool of neutrophils in alveoli of rabbit lungs. Rabbit lungs contained an estimated 6.11 x 10(4) alveolar neutrophils/g wet wt of lungs, and 9.57 x 10(5) alveolar neutrophils/rabbit. Lung lavage was successful in removing an average of 42.2% of the neutrophils in the air containing spaces of the lungs. An average of 2.5 +/- 3.5 (SD)% of the cells in the lung washes were neutrophils, but an average of 10.23 +/- 5.0 (SD)% of the cells that were free in the alveolus were neutrophils. Studies of the interaction of alveolar macrophages and neutrophils in vitro showed that neither cell phagocytoses or destroys the other in significant quantities; however, alveolar macrophages containing neutrophils have been observed.
形态测量方法以及中性粒细胞的两个独特特征使我们能够测量兔肺肺泡中中性粒细胞池的大小。兔肺中每克湿重肺组织估计含有6.11×10⁴个肺泡中性粒细胞，每只兔子有9.57×10⁵个肺泡中性粒细胞。肺灌洗成功地清除了肺含气空间中平均42.2%的中性粒细胞。肺灌洗液中平均2.5±3.5（标准差）%的细胞是中性粒细胞，但肺泡中游离细胞平均10.23±5.0（标准差）%是中性粒细胞。体外对肺泡巨噬细胞与中性粒细胞相互作用的研究表明，两种细胞都不会大量吞噬或破坏对方；然而，已观察到含有中性粒细胞的肺泡巨噬细胞。
