Park Soyeon, Song Jeongsup, Park Mi Ae, Jang Hyun-Jun, Son Seoyun, Kim Dae-Hyuk, Kim Yangseon
Department of Research and Development, Center for Industrialization of Agricultural and Livestock Microorganisms, Jeongeup 56212, Republic of Korea.
Department of Molecular Biology, Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Microorganisms. 2023 Nov 30;11(12):2890. doi: 10.3390/microorganisms11122890.
During weaning, piglets experience various stressor events that disrupt their gut microbiota and immune balance, decrease growth parameters, and increase mortality rates. In this study, we assessed the efficacy of CACC616 as a probiotic supplement. We characterized this strain and evaluated its effect on improving growth performance, modulating gut microbiota composition, and reducing noxious odor components in weaned piglets compared to a non-supplementary diet (control). During the 26-day period, 40 crossbred weaned piglets were randomly assigned to pens with 20 animals each in two groups: control and treatment groups with CACC616. On day 26, the treatment group exhibited a lower feed conversion ratio (FCR) and a significant alteration in gut microbial composition, correlating with improved growth parameters and gut health ( < 0.05). The treatment group also exhibited significantly reduced digestibility- and intestinal-environment-related noxious odor components ( < 0.05). The CACC616 strain effectively reduced pathogenic genera numbers, including , , and spp., with the treatment group exhibiting lower fecal calprotectin levels than the control group ( < 0.05). Overall, this study revealed that the functional probiotic CACC616 contributes to enhanced FCR and effectively modulates weaned piglets' inflammation and intestinal microbiota.
在断奶期间，仔猪会经历各种应激事件，这些事件会破坏其肠道微生物群和免疫平衡，降低生长参数，并增加死亡率。在本研究中，我们评估了CACC616作为益生菌补充剂的功效。我们对该菌株进行了表征，并评估了其与非补充饮食（对照）相比，对改善断奶仔猪生长性能、调节肠道微生物群组成以及减少有害气味成分的影响。在26天的时间里，40头杂交断奶仔猪被随机分配到两个组的猪栏中，每组20只动物：对照组和添加CACC616的治疗组。在第26天，治疗组的饲料转化率（FCR）较低，肠道微生物组成有显著变化，这与生长参数的改善和肠道健康相关（<0.05）。治疗组还表现出与消化率和肠道环境相关的有害气味成分显著减少（<0.05）。CACC616菌株有效减少了包括、、和 spp. 在内的致病属数量，治疗组的粪便钙卫蛋白水平低于对照组（<0.05）。总体而言，本研究表明功能性益生菌CACC616有助于提高FCR，并有效调节断奶仔猪的炎症和肠道微生物群。
