Henan Provincial Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Molecules. 2023 Dec 7;28(24):7995. doi: 10.3390/molecules28247995.
Fresh Rehmanniae Radix, as well as its processed products, are widely used in the clinical practice of traditional Chinese medicine. It is mainly available in four forms: fresh Rehmanniae Radix, raw Rehmanniae Radix, prepared Rehmanniae Radix, and nine-steamed, nine-dried Rehmanniae Radix. Pharmacological studies have shown that all Rehmanniae Radix forms contain iridoid glycosides and sugar compounds with various effects, including hypoglycemic, anti-inflammatory, neuroprotective, immunological enhancement, and bone marrow hematopoiesis-promoting activities. Differences in the efficacy among these Rehmanniae Radix forms and their processed products have been attributed to variations in their chemical compositions, particularly in iridoid glycosides and sugar compounds; however, the specific compositional differences in glycosides and sugars among the four forms of Rehmanniae Radix have not been clarified. Therefore, this study aims to qualitatively characterize the iridoid glycosides and sugar compounds in fresh Rehmanniae Radix, raw Rehmanniae Radix, prepared Rehmanniae Radix, and nine-steamed, nine-dried Rehmanniae Radix.
鲜地黄、生地黄、熟地黄和九蒸九晒地黄是中药临床应用中常用的地黄药材及其炮制品，主要有鲜地黄、生地黄、熟地黄和九蒸九晒地黄 4 种形式。药理研究表明，所有地黄形式均含有具有不同作用的环烯醚萜苷和糖化合物，包括降血糖、抗炎、神经保护、免疫增强和促进骨髓造血活性。这些地黄形式及其炮制品功效的差异归因于其化学成分的变化，特别是环烯醚萜苷和糖化合物的变化；然而，这 4 种地黄形式中环烯醚萜苷和糖化合物的具体成分差异尚未阐明。因此，本研究旨在定性分析鲜地黄、生地黄、熟地黄和九蒸九晒地黄中环烯醚萜苷和糖化合物的特征。
