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母体免疫在保护新生雪貂免受强毒力流感病毒感染中的作用。

Role of maternal immunity in the protection of newborn ferrets against infection with a virulent influenza virus.

作者信息

Husseini R H, Sweet C, Overton H, Smith H

出版信息

Immunology. 1984 Jul;52(3):389-94.

Abstract

Intranasal infection of newborn ferrets with a virulent strain of influenza virus invariably resulted in their deaths following virus replication to high titre in both lung and nasal turbinates (Collie et al., 1980). However, a similar challenge of newborn ferrets born to mothers immunized by infection with virulent or attenuated viruses resulted in complete protection; no virus replicated in their lungs and little or no virus was isolated from their nasal turbinates. Protection appeared to be antibody-mediated since it was sub-type-specific and milk-derived since newborn ferrets born to non-immune mothers but fostered onto immune mothers exhibited a similar level of protection to neonates born to and suckled by immune mothers.

摘要

用强毒株流感病毒经鼻腔感染新生雪貂,病毒在肺和鼻甲中复制到高滴度后,新生雪貂总会死亡(科利等人,1980年)。然而,对感染强毒株或减毒株病毒而免疫的母雪貂所生的新生雪貂进行类似攻击时,却能实现完全保护;病毒不在它们的肺中复制,且从它们的鼻甲中分离出的病毒很少或没有。这种保护似乎是由抗体介导的,因为它具有亚型特异性,且是源自乳汁的,因为未免疫母雪貂所生但由免疫母雪貂哺育的新生雪貂,与免疫母雪貂所生并由其哺乳的新生雪貂表现出相似水平的保护。

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