Hossmann K A, Schmidt-Kastner R, Grosse Ophoff B
J Neurol Sci. 1987 Feb;77(2-3):305-20. doi: 10.1016/0022-510x(87)90130-4.
Functional and metabolic recovery of a female cat is described which survived for 1 year following 1 hour global cerebro-circulatory arrest at normothermia. Ischemia was produced by intrathoracal occlusion of the innominate, the left subclavian and both mammary arteries. Following ischemia the animal was kept under intensive care for 46 h. EEG and evoked potentials began to recover after 3 h following ischemia, and spontaneous respiration returned promptly on the 2nd day when the animal was weaned from the respirator. The neurological deficit score declined from a maximum of 395 immediately after ischemia to 158 during the first week and to 40 within 4 weeks. At this time the animal was slightly ataxic but she was able to walk and to feed and clean herself. One year after ischemia EEG and evoked potentials were normal. Morphological studies and the autoradiographic evaluation of protein biosynthesis revealed an almost normal pattern in cortical structures but there was almost complete atrophy of dorsal hippocampus and striatum leading to enlargement of the ventricular system. These observations demonstrate that despite these lesions the central nervous system is able to recover integrative neurological function after cerebro-circulatory arrest in normothermia of as long as 1 h.
描述了一只雌性猫在常温下全脑循环停止1小时后存活1年的功能和代谢恢复情况。缺血是通过胸腔内阻断无名动脉、左锁骨下动脉和双侧乳内动脉产生的。缺血后，该动物接受了46小时的重症监护。脑电图和诱发电位在缺血后3小时开始恢复，动物在第2天撤掉呼吸机时即迅速恢复自主呼吸。神经功能缺损评分从缺血后立即出现的最高395分降至第一周的158分，并在4周内降至40分。此时，该动物有轻微共济失调，但能够行走、进食和自我清洁。缺血1年后，脑电图和诱发电位恢复正常。形态学研究和蛋白质生物合成的放射自显影评估显示皮质结构几乎正常，但背侧海马体和纹状体几乎完全萎缩，导致脑室系统扩大。这些观察结果表明，尽管存在这些损伤，中枢神经系统在常温下长达1小时的脑循环停止后仍能够恢复整合性神经功能。
