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Characterization of second primary malignancies post CAR T-cell therapy: real-world insights from the two global pharmacovigilance databases of FAERS and VigiBase.嵌合抗原受体（CAR）T细胞疗法后第二原发性恶性肿瘤的特征：来自FAERS和VigiBase这两个全球药物警戒数据库的真实世界见解
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Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti-CD19 CAR T-cell Treated Patients.抗CD19嵌合抗原受体T细胞治疗患者中克隆性造血的临床意义及动态变化
Hemasphere. 2023 Oct 3;7(10):e957. doi: 10.1097/HS9.0000000000000957. eCollection 2023 Oct.
2
Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.自体细胞移植后发生治疗相关急性髓系白血病和骨髓增生异常综合征的多发性骨髓瘤患者的特征和结局。
Transplant Cell Ther. 2024 Feb;30(2):205.e1-205.e12. doi: 10.1016/j.jtct.2023.06.015. Epub 2023 Jul 10.
3
Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma.阿基仑赛治疗大 B 细胞淋巴瘤的总生存。
N Engl J Med. 2023 Jul 13;389(2):148-157. doi: 10.1056/NEJMoa2301665. Epub 2023 Jun 5.
4
Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma.西达基奥仑赛或标准护理用于来那度胺难治性多发性骨髓瘤。
N Engl J Med. 2023 Jul 27;389(4):335-347. doi: 10.1056/NEJMoa2303379. Epub 2023 Jun 5.
5
Impact of second primary malignancy post-autologous transplantation on outcomes of multiple myeloma: a CIBMTR analysis.自体移植后第二原发恶性肿瘤对多发性骨髓瘤结局的影响：CIBMTR 分析。
Blood Adv. 2023 Jun 27;7(12):2746-2757. doi: 10.1182/bloodadvances.2022009138.
6
Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma.伊达赛利珠单抗或标准方案治疗复发/难治性多发性骨髓瘤。
N Engl J Med. 2023 Mar 16;388(11):1002-1014. doi: 10.1056/NEJMoa2213614. Epub 2023 Feb 10.
7
Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering.新型外显基因安全港，用于精确的治疗性 T 细胞工程。
Blood. 2023 Jun 1;141(22):2698-2712. doi: 10.1182/blood.2022018924.
8
Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study.自体抗 BCMA 嵌合抗原受体 T 细胞（liso-cel）治疗二线弥漫大 B 细胞淋巴瘤（DLBCL）的 3 期 TRANSFORM 研究的主要分析结果
Blood. 2023 Apr 6;141(14):1675-1684. doi: 10.1182/blood.2022018730.
9
Patient-reported outcomes in ZUMA-7, a phase 3 study of axicabtagene ciloleucel in second-line large B-cell lymphoma.ZUMA-7 研究中的患者报告结局，该研究是一项评估 axicabtagene ciloleucel 在二线大 B 细胞淋巴瘤中的 3 期研究。
Blood. 2022 Nov 24;140(21):2248-2260. doi: 10.1182/blood.2022015478.
10
Patient preferences for treatment in relapsed/refractory diffuse large B-cell lymphoma: a discrete choice experiment.患者对复发/难治性弥漫性大 B 细胞淋巴瘤治疗的偏好：一项离散选择实验。
Future Oncol. 2022 Aug;18(25):2791-2804. doi: 10.2217/fon-2022-0421. Epub 2022 Jul 15.

Answering the "Doctor, can CAR-T therapy cause cancer?" question in clinic.

作者信息

Banerjee Rahul, Poh Christina, Hirayama Alexandre V, Gauthier Jordan, Cassaday Ryan D, Shadman Mazyar, Cowan Andrew J, Till Brian G, Green Damian J, Kiem Hans-Peter, Gopal Ajay K, Maloney David G

机构信息

Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA.

Department of Medicine, University of Washington, Seattle, WA.

出版信息

Blood Adv. 2024 Feb 27;8(4):895-898. doi: 10.1182/bloodadvances.2023012336.

DOI:10.1182/bloodadvances.2023012336
PMID:38197942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10875255/
Abstract
摘要