Nanjing University, Affiliated Hospital of Medical School, Nanjing Stomatological Hospital, Department of Periodontology, Nanjing, China.
Nanjing University, Affiliated Hospital of Medical School, Nanjing Stomatological Hospital, Department of Orthodontic, Nanjing, China.
J Appl Oral Sci. 2024 Jan 5;32:e20230268. doi: 10.1590/1678-7757-2023-0268. eCollection 2024.
This retrospective study aimed to analyze the clinical efficacy of two regenerative surgical methods - Bio-Oss granules combined with barrier membranes and Bio-Oss Collagen alone - and to help clinicians achieve better periodontal regeneration outcomes in the specific periodontal condition.
Patients who underwent periodontal regeneration surgery from January 2018 to April 2022 were retrospectively screened, and their clinical and radiographic outcomes at 6 months postoperatively were analyzed. The probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival recession (GR), distance from the cemento-enamel junction to the bottom of the bone defect (CEJ-BD), and depth of intrabony defects (INFRA) were recorded before the operation (T0) and 6 months after it (T1), and subsequently compared.
In total, 143 patients were included - 77 were placed in the Bio-Oss group and 66 were placed in the Bio-Oss Collagen group. All indicators, including PD and CAL at T1, showed significant differences compared to baseline, for both groups (P<0.001). PD reduction was greater in the group receiving the Bio-Oss Collagen treatment (P=0.042). Furthermore, in cases when the baseline PD range was 7-11 mm and the age range was 35-50 years, PD reduction was more significant for patients receiving the Bio-Oss Collagen treatment (P=0.031, 0.023). A linear regression analysis indicated that postoperative PD and CAL were positively correlated with baseline values, and that the efficacy tended to decrease with increasing age.
Both the use of Bio-Oss Collagen alone and the use of Bio-Oss granules combined with barrier membranes resulted in significant effects in the treatment of periodontal intrabony defects. The Bio-Oss Collagen treatment generated more improvements in PD than the Bio-Oss granules combined with barrier membranes, particularly within the baseline PD range of 7-11 mm and the 35-50 years age group. Additionally, age was the main factor influencing the effectiveness of regenerative surgery for intrabony defects: older individuals exhibited fewer improvements.
本回顾性研究旨在分析两种再生手术方法的临床疗效- Bio-Oss 颗粒联合屏障膜和单独使用 Bio-Oss 胶原-并帮助临床医生在特定牙周状况下实现更好的牙周再生效果。
回顾性筛选 2018 年 1 月至 2022 年 4 月期间接受牙周再生手术的患者，并分析其术后 6 个月的临床和影像学结果。在手术前（T0）和术后 6 个月（T1）记录探诊深度（PD）、临床附着水平（CAL）、探诊出血（BOP）、牙龈退缩（GR）、牙骨质-釉牙骨质界到骨缺损底部的距离（CEJ-BD）和骨内缺损深度（INFRA），然后进行比较。
共纳入 143 例患者-77 例患者纳入 Bio-Oss 组，66 例患者纳入 Bio-Oss 胶原组。两组在 T1 时的所有指标，包括 PD 和 CAL，与基线相比均有显著差异（P<0.001）。接受 Bio-Oss 胶原治疗的患者 PD 减少更明显（P=0.042）。此外，在基线 PD 范围为 7-11mm，年龄范围为 35-50 岁的情况下，接受 Bio-Oss 胶原治疗的患者 PD 减少更明显（P=0.031，0.023）。线性回归分析表明，术后 PD 和 CAL 与基线值呈正相关，且疗效随年龄增加而降低。
单独使用 Bio-Oss 胶原和使用 Bio-Oss 颗粒联合屏障膜治疗牙周骨内缺损均有显著效果。与 Bio-Oss 颗粒联合屏障膜相比，Bio-Oss 胶原治疗在 PD 方面的改善更为明显，特别是在基线 PD 范围为 7-11mm 和 35-50 岁年龄组。此外，年龄是影响骨内缺损再生手术效果的主要因素：年龄较大的患者改善较少。
