Swaidan Aseel, Azakir Bilal, Neugart Susanne, Kattour Naim, Sokhn Elie Salem, Osaili Tareq M, Darra Nada El
Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, Tarik El Jedidah, Riad El Solh, P.O. Box 115020, Beirut 1107 2809, Lebanon.
Molecular and Translational Medicine Laboratory, Faculty of Medicine, Beirut Arab University, Beirut 1107 2809, Lebanon.
Foods. 2023 Dec 29;13(1):126. doi: 10.3390/foods13010126.
Date seeds, which are the main by-products of date fruit consumption, were shown to possess promising biological activities and health benefits with minimal human use. The present investigation analyzed and compared the phenolic content of six date seed varieties from four different origins (Khudari, Sakai, and Safawi from Saudi Arabia, Majdool from Jordan, Zahdi from Iraq, and Kabkab from Iran). The aqueous extracts were examined for possible antioxidant, antibacterial, and anti-tumor potential. Date seed oil was extracted, and fatty acid profiles were compared. The results revealed that date seeds are a rich source of polyphenols, which have been linked to biological activities. Furthermore, the phenolic content seemed highly dependent on the variety, where Kabkab had the highest TPC value (271.2 mg GAE/g DM) while Majdool had the lowest value (63.2 mg GAE/g DM). Antioxidant activities of all varieties were highly correlated with the total phenolic content. The antibacterial investigation demonstrated that the Sakai variety possessed the dominant activity, whereas Majdool showed no activity. The results further indicated the sensitivity of both and , with a stronger effect against , while no effect was observed against Gram-negative strains ( Typhi and ). All varieties were able to decrease colon and lung cancer cell viability, especially Khudari and Sakai, with stronger effects against colon cancer cells. Analysis of date seed oil showed high oleic acid content, especially in Sakai. The findings suggest that date seeds are promising candidates for future pharmaceutical applications as nutraceuticals to help combat certain illnesses, as well as functional foods and natural additives that boost the nutritional value of food products, increase their shelf lives, and improve the overall health of consumers.
海枣种子是海枣果实消费的主要副产品，已显示出具有可观的生物活性和健康益处，且对人体的使用极少。本研究分析并比较了来自四个不同产地的六个海枣种子品种（沙特阿拉伯的胡达里、酒椰和萨法维，约旦的马吉杜勒，伊拉克的扎赫迪，以及伊朗的卡布卡）的酚类含量。对水提取物的抗氧化、抗菌和抗肿瘤潜力进行了检测。提取了海枣籽油，并比较了脂肪酸谱。结果表明，海枣种子是多酚的丰富来源，而多酚与生物活性有关。此外，酚类含量似乎高度依赖于品种，其中卡布卡的总酚含量最高（271.2毫克没食子酸当量/克干物质），而马吉杜勒的含量最低（63.2毫克没食子酸当量/克干物质）。所有品种的抗氧化活性与总酚含量高度相关。抗菌研究表明，酒椰品种具有主要活性，而马吉杜勒没有活性。结果进一步表明了对[此处原文缺失两种细菌名称]均敏感，对[此处原文缺失一种细菌名称]的作用更强，而对革兰氏阴性菌株（伤寒杆菌和[此处原文缺失一种细菌名称]）没有作用。所有品种都能够降低结肠癌细胞和肺癌细胞的活力，尤其是胡达里和酒椰，对结肠癌细胞的作用更强。海枣籽油分析显示油酸含量很高，尤其是在酒椰中。研究结果表明，海枣种子有望作为营养保健品用于未来的药物应用，以帮助对抗某些疾病，同时也可作为功能性食品和天然添加剂，提高食品的营养价值、延长其保质期并改善消费者的整体健康状况。
