Adamuz-Jiménez Ana, Manzano-Moreno Francisco-Javier, Vallecillo Cristina
Faculty of Dentistry, Colegio Máximo de Cartuja s/n, University of Granada, 18071 Granada, Spain.
Biomedical Group (BIO277), Department of Stomatology, University of Granada, 18071 Granada, Spain.
Polymers (Basel). 2023 Dec 28;16(1):95. doi: 10.3390/polym16010095.
Both guided bone and guided tissue regeneration are techniques that require the use of barrier membranes. Contamination and infection of the surgical area is one of the most feared complications. Some current lines of research focus on functionalizing these membranes with different antimicrobial agents. The objective of this study was to carry out a review of the use and antibacterial properties of regeneration membranes doped with antimicrobials such as zinc, silver, chlorhexidine, and lauric acid. The protocol was based on PRISMA recommendations, addressing the PICO question: "Do membranes doped with non-antibiotic antimicrobials have antibacterial activity that can reduce or improve infection compared to membranes not impregnated with said antimicrobial?" Methodological quality was evaluated using the RoBDEMAT tool. A total of 329 articles were found, of which 25 met the eligibility criteria and were included in this review. Most studies agree that zinc inhibits bacterial growth as it decreases colony-forming units, depending on the concentration used and the bacterial species studied. Silver compounds also decreased the secretion of proinflammatory cytokines and presented less bacterial adhesion to the membrane. Some concentrations of chlorhexidine that possess antimicrobial activity have shown high toxicity. Finally, lauric acid shows inhibition of bacterial growth measured by the disk diffusion test, the inhibition zone being larger with higher concentrations. Antimicrobial agents such as zinc, silver, chlorhexidine, and lauric acid have effective antibacterial activity and can be used to dope regenerative membranes in order to reduce the risk of bacterial colonization.
引导骨再生和引导组织再生都是需要使用屏障膜的技术。手术区域的污染和感染是最令人担忧的并发症之一。目前一些研究方向集中在使用不同的抗菌剂使这些膜功能化。本研究的目的是综述掺杂有锌、银、洗必泰、月桂酸等抗菌剂的再生膜的使用情况和抗菌特性。该方案基于PRISMA建议，解决了PICO问题：“与未浸渍所述抗菌剂的膜相比，掺杂有非抗生素抗菌剂的膜是否具有可降低或改善感染的抗菌活性？”使用RoBDEMAT工具评估方法学质量。共检索到329篇文章，其中25篇符合纳入标准并被纳入本综述。大多数研究一致认为，锌可抑制细菌生长，因为它能减少菌落形成单位，这取决于所使用的浓度和所研究的细菌种类。银化合物还可减少促炎细胞因子的分泌，且膜上的细菌粘附较少。一些具有抗菌活性的洗必泰浓度显示出高毒性。最后，通过纸片扩散试验测得月桂酸可抑制细菌生长，浓度越高抑菌圈越大。锌、银、洗必泰、月桂酸等抗菌剂具有有效的抗菌活性，可用于掺杂再生膜以降低细菌定植的风险。
