Pawlikowski M, Stepien H, Mroz-Wasilewska Z, Pawlikowska A
Life Sci. 1987 Mar 16;40(11):1131-5. doi: 10.1016/0024-3205(87)90577-7.
The effect of a single dose (5mg/kg b.w.) of diazepam on the cell proliferation in selected organs of 11-day old female Sprague-Dawley rats has been investigated. The stathmokinetic method (counting of mitoses after colchicine administration) has been used for evaluation of cell replication. The significant fall of the mitotic activity in the parietal cerebral cortex and the anterior pituitary gland was found. On the other hand, the increase of the mitotic activity in thymus was observed. The reported data, taken together with the previous observations from our and other laboratories, suggest the involvement of benzodiazepine receptor in the control of cell proliferation.
研究了单剂量（5毫克/千克体重）地西泮对11日龄雌性斯普拉格-道利大鼠选定器官中细胞增殖的影响。采用静止动力学方法（秋水仙碱给药后计数有丝分裂）评估细胞复制。发现顶叶大脑皮质和垂体前叶的有丝分裂活性显著下降。另一方面，观察到胸腺中有丝分裂活性增加。这些报告的数据，连同我们实验室和其他实验室先前的观察结果，表明苯二氮䓬受体参与细胞增殖的控制。
